A Perinatal Strategy For Preventing Adult Disease: The Role Of Long-Chain Polyunsaturated Fatty Acids

Undurti N. Das (Autor)

Buch | Softcover

192 Seiten

2012 | Softcover reprint of the original 1st ed. 2002
Springer-Verlag New York Inc.
978-1-4613-4638-8 (ISBN)

Artikel merken

Obesity, type 2 diabetes mellitus,hypertension, and coronary heart disease are serious diseases affecting asignificantnumberofadults across the globe. Insulin resistance, low-grade systemic inflammation, low-birth weight,maternalproteinmalnutrition,neonatalhighcarbohydratediet,and high fat diet are associated with these diseases. On the other hand, adequatelybreast-fedsubjects are substantially at lowerrisk. Ifso,whatis the linkbetweenthese variousfactors?Onepossibilityisthat humanbreast milk containsfactorsthatconferresistancetothese modemdiseases.Here I present arguments that long-chain polyunsaturated fatty acids (LCPUFAs) presentinthebreastmilkcouldberesponsibleforthisbeneficialaction. Though the entire class of LCPUFAs provided dunng perinatal periodislikelytohavearole inthepreventionofadultdiseases,itshouldbe understoodthateachofthese LCPUFAsexhibitauniqueand insome cases opposing bioactive properties.It is important to note that there is a close interaction between (0-6 and (0-3 fatty acids. Human breast rmlk contains almost twice (0.78 vs 0.4
3 %w/w)the amountof(0-6LCPUFAs (gamma- linolenic acid, dihomo-gamma-linolenic acid and arachidonic acid) comparedto (0-3LCPUFAs(eicosapentaenoicacid,docosapentaenoicacid, and docosahexaenoic acid). Obviously, the best would be to mimic the composition/concentrations in which these fatty acids are present in the breastmilk. The conceptthat LCPUFAs given duringpennatalperiod(and inadultlife)isbeneficialinpreventingadultdiseasescertainlyneedsfurther exploration.Iamconfidentthat someofthe enterprisingreaderswill delve intothepossibilitiessuggestedafterreadingthisbook. UndurtiN.Das,M.D.,FAMS. To MyWifeLakshmi and Mytwoeyes DaughterArundhatiandSonAditya Chapter #1 Introduction Fetal/Perinatalimprintingonlaterlife It isbelievedthat stimuliormsults during criticalorsensitiveperiods inearlylifecanhave lifetimeconsequences.Thisconceptiswellestablished in developmental biology and has been termed "programming". The evidence for programming confirmed the critical period for imprinting in animals, more so in birds'. Programming stimuli may be generated endogenously, such as hormonal signals', or they may be environmental.

1 Introduction Fetal/Perinatal imprinting on later life.- 2 Perinatal origins of adult disease Obesity.- 3 Perinatal origins of adult disease Insulin resistance and Diabetes mellitus.- 4 Perinatal origins ofadult disease Hypertension.- 5 Perinatal origins of adult disease Coronary heart disease.- 6 Metabolic Syndrome X and low-grade systemic inflammation.- 7 Long-chain polyunsaturated fatty acids in adult diseases: A hypothesis.- 8 Breast-feeding Composition and benefits.- 9 Long-chain polyunsaturated fatty acids Metabolism, physiology and clinical significance.- lO A perinatal strategy to prevent adult diseases: The Role of long-chain polyunsaturated fatty acids Clinical implications and testing the hypothesis.

Zusatzinfo	192 p.
Verlagsort	New York, NY
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizinische Fachgebiete ► Innere Medizin ► Kardiologie / Angiologie
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pädiatrie
ISBN-10	1-4613-4638-X / 146134638X
ISBN-13	978-1-4613-4638-8 / 9781461346388
Zustand	Neuware