RNA Interference (eBook)

Application to Drug Discovery and Challenges to Pharmaceutical Development

Paul H. Johnson (Herausgeber)

eBook Download: PDF | EPUB

2011
John Wiley & Sons (Verlag)
978-0-470-93467-8 (ISBN)

Infos

RNA Interference: Application to Drug Discovery and Challenges to Pharmaceutical Development provides a general overview of this rapidly emerging field, with a strong emphasis on issues and aspects that are important to a drug development team. The first part covers more general background of RNA interference and its application in drug discovery. In the second part, the book addresses siRNA (small interfering RNA), a pharmaceutically potent form, and its use and delivery in therapeutics along with manufacturing and delivery aspects.

PAUL H. JOHNSON, PhD, is a cofounder and Chief Scientific Officer at PhaseRx, Inc. He is the author of numerous scientific papers and patents, and was the recipient of the 2007 Jeffrey Wenig Memorial Award for Outstanding Achievement in Drug Delivery.

Inhalt

RNA INTERFERENCE 3
CONTENTS 7
CONTRIBUTORS 9
PREFACE 11
FOREWORD 15
I BIOLOGY OF RNA INTERFERENCE 17
1 RNA INTERFERENCE: WHAT IS IT? 19
2 NUCLEIC ACIDS AS REGULATORY MOLECULES 28
3 USE OF SIRNA OLIGONUCLEOTIDES TO STUDY GENE FUNCTION 66
4 GENOME SCANNING BY RNA INTERFERENCE 92
II DEVELOPMENT OF SIRNA FOR THERAPEUTIC APPLICATIONS 139
5 DISCOVERY OF NEW SIRNA DELIVERY AGENTS 141
6 SIRNA DELIVERY VEHICLES 190
7 INTERFERON, CYTOKINE INDUCTION, AND OTHER POTENTIAL IN VIVO TOXICITIES 232
8 APPLICATION OF RNA INTERFERENCE TO VIRAL DISEASES 288
INDEX 323
Color Plate 327

Rezensionen

"This is an accessible book that approaches the goal of therapeutic RNAi delivery from a technological viewpoint. Chapter organization and figure presentation allow for interrupted reading without disrupting the flow. Cell and molecular biologists will find both interesting details and practical methods to improve the preclinical applicability of a research project. While therapeutic RNAi is still largely in the development stage, this book promotes a mindset to continue the search for effective delivery strategies." (Doody's, 7 October 2011)

Produkt-Details

• Erscheint lt. Verlag: 1.3.2011
• Vorwort: John J. Rossi
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie
• Themenwelt: Naturwissenschaften ► Biologie
• Themenwelt: Naturwissenschaften ► Chemie
• Schlagworte: academic labs • action • Applications • Biotechnologie i. d. Chemie • Biotechnology • Biowissenschaften • Book • Cell & Molecular Biology • Chemie • Chemistry • Drug Discovery & Development • emerging • extensively • Gene • General • Industry • Interference • Life Sciences • mechanisms • Molecules • NOVICE • Overview • Pharmaceutical • rapidly • reader today • RNA • target • therapeutics • unfamiliar • Wirkstoffforschung • Wirkstoffforschung u. -entwicklung • Zell- u. Molekularbiologie
• ISBN-10: 0-470-93467-0 / 0470934670
• ISBN-13: 978-0-470-93467-8 / 9780470934678