Metabolic Syndrome (eBook)

Underlying Mechanisms and Drug Therapies

Minghan Wang (Herausgeber)

eBook Download: PDF | EPUB

2011
John Wiley & Sons (Verlag)
9780470922712 (ISBN)

Infos

This book provides a comprehensive overview of the development of metabolic syndrome, the underlying mechanisms and therapeutic strategies for drug development. The authors examine the context of underlying molecular pathways and integrated physiology, then expanding the discussion to diseases associated with metabolic syndrome. The development of drug therapies for these diseases and complications is extensively covered. The book offers a comprehensive and in-depth view of energy metabolism, metabolic tissues and pathways, molecular mechanism-based drug discovery and clinical implications.

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METABOLIC SYNDROME A comprehensive look at the fight against the metabolic syndrome epidemic Increasing risk of cardiovascular disease and diabetes, the metabolic syndrome is a world health problem that demands attention from all levels of the health care industry. Metabolic Syndrome: Underlying Mechanisms and Drug therapies extensively covers the metabolic syndrome with an emphasis on drug discovery efforts, providing a context of molecular mechanisms and drug pharmacology for pharmaceutical scientists. The book starts by examining the physiology of metabolic tissues under normal and disease states, followed by discussions of metabolic diseases and clinical complications. The development of drug therapies based on emerging science is then covered extensively. In addition, there is an in-depth look into the metabolic pathways and dysfunctions in metabolic disease, especially type 2 diabetes and lipid disorders. Finally, a chapter is devoted to past successes and failures in metabolic drug discovery as well as an outlook on future development and challenges. Divided into four parts, the book: Addresses important metabolic syndrome basics at the psychological level and metabolic abnormalities at the tissue and pathway levels Covers the identification of pathways and molecular targets for the development of anti-diabetic therapies Details pharmaceutical industry approach to solving metabolic and obesity related problems Describes drug therapies and their limitations and complications, offering a lessons learned from existing treatments With a clear organization and extensive collection of references, the book is a user-friendly and unique tool for scientists in a variety of scientific disciplines in the pharmaceutical and biotechnology industries.

Autor

MINGHAN "MING" WANG, PHD is Director and head of a metabolism group in Metabolic Disorders Research at Amgen. He has authored over forty publications and is a regular speaker at drug discovery conferences.

Inhalt

Metabolic Syndrome Underlying Mechanisms and Drug Therapies 1
Contents 7
Introduction 11
Contributors 13
Part One: The Physiology of Metabolic Tissues Under Normal and Disease States 17
1: Gut as an Endocrine Organ: the Role of Nutrient Sensing in Energy Metabolism 19
2: Central Glucose Sensing and Control of Food Intake and Energy Homeostasis 45
3: Abnormalities in Insulin Secretion in Type 2 Diabetes Mellitus 69
4: Adipokine Production by Adipose Tissue: A Novel Target for Treating Metabolic Syndrome and its Sequelae 89
5: Hepatic Metabolic Dysfunctions in Type 2 Diabetes: Insulin Resistance and Impaired Glucose Production and Lipid Synthesis 149
6: Energy Metabolism in Skeletal Muscle and its Link to Insulin Resistance 173
Part Two: Metabolic Diseases and Current Therapies 193
7: Mechanisms and Complications of Metabolic Syndrome 195
8: Emerging Therapeutic Approaches for Dyslipidemias Associated with High LDL and Low HDL 215
9: Mechanism of Action of Niacin: Implications for Atherosclerosis and Drug Discovery 251
10: Current Antidiabetic Therapies and Mechanisms 269
Part Three: Drug Targets for Antidiabetic Therapies 295
11: GLP-1 Biology, Signaling Mechanisms, Physiology, and Clinical Studies 297
12: Dipeptidyl Peptidase IV Inhibitors for Treatment of Diabetes 343
13: Sodium Glucose Cotransporter 2 Inhibitors 375
14: Fibroblast Growth Factor 21 as a Novel Metabolic Regulator 393
15: Sirtuins as Potential Drug Targets for Metabolic Diseases 407
16: 11?-Hydroxysteroid Dehydrogenase Type 1 as a Therapeutic Target for Type 2 Diabetes 439
17: Monoclonal Antibodies for the Treatment of Type 2 Diabetes: A Case Study with Glucagon Receptor Blockade 475
Part Four: Lessons Learned and Future Outlook 485
18: Drug Development for Metabolic Diseases: Past, Present, and Future 487
Index 505

Rezensionen

"This is an outstanding addition to the current body of work on the metabolic syndrome. I thought it particularly exhaustive in its review of the literature, making it an excellent resource for scouring the primary literature, and found the duality of current and future treatment approaches particularly insightful." (Doody's, 21 October 2011)

"The book offers a comprehensive and in-depth view of energy metabolism, metabolic tissues and pathways, molecular mechanism-based drug discovery and clinical implications." (Pharmiweb, 1 March 2011)

Produkt-Details

• Erscheint lt. Verlag: 18.4.2011
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie
• Themenwelt: Naturwissenschaften ► Chemie
• Schlagworte: Chemie • Chemistry • Diabetes • Drug Discovery & Development • Medical Science • Medizin • Pharmacology & Pharmaceutical Medicine • Pharmakologie • Pharmakologie u. Pharmazeutische Medizin • Wirkstoffforschung u. -entwicklung
• ISBN-13: 9780470922712 / 9780470922712