Oral Precancer (eBook)

Diagnosis and Management of Potentially Malignant Disorders

Peter Thomson (Herausgeber)

eBook Download: PDF

2012
John Wiley & Sons (Verlag)
978-1-118-34642-6 (ISBN)

Infos

Without early detection, oral cancer is deadly. Protect your patients by applying the latest clinical interventions.

Rates of new oral cancer cases continue to increase and mortality rates remain alarmingly high. Oral
cancer may be preceded by clinically identifiable precancerous changes in the oral mucosa, which offer a therapeutic window of opportunity to intervene and halt disease progression to carcinoma development.

Written and edited by prominent researchers in the field, Oral Precancer:

• Reviews current scientific research on precancer conditions of the oral cavity providing evidence-based analysis of the nature and behavior of potentially malignant and deforming oral diseases
• Explains the principles of prevention, diagnosis and management of potentially malignant disorders of the oral cavity
• Details a practical and reliable interventional treatment strategy to facilitate early diagnosis and effective treatment of both precancer and early invasive carcinoma
• Contains a chapter devoted to illustrative case histories, high-quality, color, clinical photos, reference sections in each chapter listing relevant review articles, and more

From start to finish, Oral Precancer offers undergraduate students, clinicians, and professors an invaluable resource to minimise the morbidity and mortality of this most significant and life threatening of oral conditions.

Autor

Peter Thomson is Professor of Oral and Maxillofacial Surgery at Newcastle University and Honorary Consultant in Oral and Maxillofacial Surgery at Newcastle upon Tyne Hospitals NHS Foundation Trust. In recognition of his research into oral cancer & precancer, he has been awarded both a Hunterian Professorship from the Royal College of Surgeons of England & a King James IV Professorship from the Royal College of Surgeons in Edinburgh.

Inhalt

ORAL PRECANCER: DIAGNOSIS AND MANAGEMENT OF POTENTIALLY MALIGNANT DISORDERS 1
Contents 7
List of Contributors 11
Preface 13
Acknowledgements 15
1 Introduction 17
General Introduction 18
Epidemiology 22
Prevalence of Oral Leukoplakia 23
Prevalence of Oral Erythroplakia 24
Prevention 24
Treatment Strategies 25
Terminology 25
Summary 27
References 28
2 Form and Function of the Oral Mucosa 29
Introduction 30
Applied Anatomy of the Oral Cavity 30
Function of the Oral Mucosa 33
Microanatomy of the Oral Mucosa 33
Regional Variation of the Oral Mucosa 35
Oral Epithelial Cell Kinetics 39
Oral Epithelial Cell Proliferative Activity 41
Anatomical Site Predilection for Oral Carcinogenesis 45
Summary 45
References 46
3 Oral Carcinogenesis 47
Introduction 48
Oral Cancer and Precancer 49
The ‘Progression Model’ for Oral Cancer 52
Aetiology and Risk Factors 54
Patient and Risk Factor Profiling 60
Summary 61
References 62
4 Clinical Presentation of Oral Precancer 64
Introduction 65
Clinical Terminology 65
Precancerous (Premalignant) Lesions 67
Precancerous (Premalignant) Conditions 79
Syphilis 86
Multiple Lesion Disease 87
Summary 89
References 89
5 Diagnostic Methods 91
Introduction 92
Screening 92
Clinical Examination Techniques 93
Diagnostic Aids in Precancer Diagnosis 100
Brush Biopsy and Exfoliative Cytology 104
Clinical Diagnosis in Practice 107
Summary 107
References 107
6 Pathological Aspects of Oral Precancer 109
Introduction 110
Biopsy Techniques 110
Role of the Pathologist 112
Histopathological Features of Oral Potentially Malignant Disorders 113
Grading of Dysplasia 115
Limitations in Conventional Pathological Techniques 120
Summary 121
References 121
7 Management of Oral Precancer 123
Introduction 124
Risk Factor Modification 125
Observation Versus Intervention 127
Medical Treatment 128
Surgical Treatment 129
Combined Treatment Modalities 150
Patient Follow Up and Surveillance 150
Summary 151
References 152
8 Clinical Outcome 154
Introduction 155
Clinical Outcome Studies 155
Patient Cohort Studies 157
Definitions of Clinical Outcome 158
Newcastle Patient Cohort Studies 161
Patient Follow Up 165
Prediction of Clinical Outcome 166
Summary 171
References 171
9 Malignant Transformation and Oral Cancer Development 172
Introduction 173
Risk of Progression to Oral Carcinoma 174
Malignant Transformation Versus Oral Cancer Development 177
Interventional Laser Surgery and Oral Cancer Prevention 179
Newcastle 10-Year Follow-Up Study 180
High- and Low-Risk Patients 181
Clinical Signs of Oral Squamous Cell Carcinoma 181
Diagnosis and Management of ‘Unexpected Malignancy’ 183
Prognosis for the ‘Transformed’ Patient 184
Summary 184
References 185
10 The Future 186
Introduction 187
Prevention of Oral Precancer 188
Early Diagnosis of Potentially Malignant Disease 190
Interventional Management Strategies in the Future 191
Individualised Patient Treatments: Biomarkers and Targeted Chemoprevention 194
Future Research Directions 195
Summary 199
References 200
11 Case Histories 202
Introduction 203
Case 1: Diagnosis of Unexpected Malignancy 203
Case 2: Multiple Lesion Disease Responding to Conservative Management 205
Case 3: Multiple Lesion Disease Requiring Repeated Laser Treatments 207
Case 4: Proliferative Verrucous Leukoplakia 208
Case 5: Localised Oral Lichenoid Reaction 210
Case 6: Multiple Oral Lichenoid Reactions 211
Case 7: Widespread Dysplastic Oral Lichenoid Lesions 212
Case 8: An Immunosuppressed Patient 214
Case 9: Chronic Hyperplastic Candidosis 215
Case 10: Tobacco-Associated Hyperkeratosis 217
Case 11: Malignant Transformation in Longstanding Non-Erosive Lichen Planus 219
Summary 221
12 Conclusions 223
Oral Cancer 224
Potentially Malignant Disorders 224
Clinical Management 224
Patient Care Pathways 226
Public Health Strategies 227
Future Directions 227
Index 229

Rezensionen

"I would highly recommend the book for those wishing to
expand their knowledge on oral malignancy at a specialist trainee
or higher level." (British Dental Journal, 12
October 2013)

Produkt-Details

• Erscheint lt. Verlag: 24.1.2012
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
• Themenwelt: Medizin / Pharmazie ► Zahnmedizin
• Schlagworte: Addition • application • Basis • Book • Brings • Cavity • Clinical • Conditions • dentistry • disparate • evidencebased • Information • Interventional • Latest • Oral • Oralpathologie • Oral Pathology • Precancer • Protocol • Rational • Research • Scientific • Sources • specific • Survey • Zahnmedizin
• ISBN-10: 1-118-34642-4 / 1118346424
• ISBN-13: 978-1-118-34642-6 / 9781118346426