Alcohol Metabolism, Alcohol Intolerance, and Alcoholism

Biochemical and Pharmacogenetic Approaches

Dharam P. Agarwal, H. Werner Goedde (Autoren)

Buch | Softcover

X, 184 Seiten

2011
Springer Berlin (Verlag)
978-3-642-74906-3 (ISBN)

Artikel merken

Alcohol abuse, alcohol intolerance, alcohol dependence and other alcohol-related disabilities are some of the most challenging public health problems facing our modern-day society. The purpose of this comprehensive monograph is to review the available knowledge concerning the pharmacogenetic basis of alcohol sensitivity and its physiolgical implications and to synthesize the bulk of existing knowledge regarding metabolic features and biomedical disturbances related to alcoholism. The chapters cover a broad array of disciplines including an overview of historical and epidemiological aspects, biochemistry and molecular genetics of enzymes involved in alcohol metabolism, biochemical and neuropsychopharmacological effects of alcohol. Major emphasis is placed on the role of genetic factors in alcoholism. The experimental details are summarized and a comprehensive bibliography is included.

1 Introduction.- 2 Alcohol Metabolism: Biochemistry and Genetic Variations.- 2.1Absorption, Body Distribution, and Elimination of Ethanol.- 2.2 Biochemical Pathways of Ethanol Degradation.- 3 Alcohol-Metabolizing Enzymes and Acute Reactions to Alcohol.- 3.1Ethanol- and Acetaldehyde-Mediated Acute Response to Alcohol.- 3.2 Ethnic Differences in Acute Response to Alcohol 53.- 3.3 Mechanism of Alcohol Sensitivity.- 3.4 Racial-Ethnic Patterns of Alcohol Abuse and Alcoholism.- 4Biochemical Aspects of Alcoholism.- 4.1 Alcohol-Related Metabolic Derangements.- 4.2 Metabolic Changes.- 4.3Changes in Alcohol-Metabolizing Enzymes in Alcohol-Related Disorders.- 4.4Biochemical Markers of Alcohol Abuse and Alcoholism.- 5Neuropsychopharmacology of Alcoholism.- 5.1 Alcohol Effects in the CNS.- 5.2Addiction, Tolerance, and Dependence.- 5.3Metabolic Factors.- 6Genetic Factors in Alcoholism.- 6.1 Ethnic and Cultural Variables.- 6.2 Familial and Nonfamilial Alcoholism.- 6.3 Genetic Contributions.- 6.4Genetic and Environmental Interactions in Alcoholism.- 6.5Biological Mediators of Alcoholism.- 7Experimental Section.- 7.1Subjects and Materials.- 7.2Methods.- References 145.- Subject Index 179.

Erscheint lt. Verlag	6.12.2011
Zusatzinfo	X, 184 p. 1 illus. in color.
Verlagsort	Berlin
Sprache	englisch
Maße	155 x 235 mm
Gewicht	311 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete
Themenwelt	Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie
Schlagworte	Alcoholic intolerance • Alcoholic metabolism • alcoholism • Alcohol use and abuse • Genetics • Metabolic disease
ISBN-10	3-642-74906-2 / 3642749062
ISBN-13	978-3-642-74906-3 / 9783642749063
Zustand	Neuware