Spine Technology Handbook (eBook)

Avram Edidin, Steven M. Kurtz (Autoren)

eBook Download: PDF

2006 | 1. Auflage
560 Seiten
Elsevier Science (Verlag)
978-0-08-045937-0 (ISBN)

Infos

"Over the past decade, there has been rapid growth in bioengineering applications in the field of spine implants. This book explains the technical foundation for understanding and expanding the field of spine implants, reviews the major established technologies related to spine implants, and provides reference material for developing and commercializing new spine implants. The editors, who have a track record of collaboration and editing technical books, provide a unified approach to this topic in the most comprehensive and useful book to date.

?Related website provides the latest information on spine technology including articles and research papers on the latest technology and development.
?Major technologies reviewed include devices used for fusion (screws, plates, rods, and cages), disc repair and augmentation, total disc replacement, and vertebral body repair and augmentation.
?Technology landscape, review of published/public domain data currently available, and safety and efficacy of technology discussed in detail."

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Over the past decade, there has been rapid growth in bioengineering applications in the field of spine implants. Spine Technology Handbook explains the technical foundation for understanding and expanding the field of spine implants, reviews the major established technologies related to spine implants, and provides reference material for developing and commercializing new spine implants. The editors, who have a track record of collaboration and editing technical books, provide a unified approach to this topic in the most comprehensive and useful book to date. - Related website provides the latest information on spine technology including articles and research papers on the latest technology and development- Major technologies reviewed include devices used for fusion (screws, plates, rods, and cages), disc repair and augmentation, total disc replacement, and vertebral body repair and augmentation- Technology landscape, review of published/public domain data currently available, and safety and efficacy of technology discussed in detail

Inhalt

Front cover 1
Title page 5
Copyright page 6
Table of contents 9
Contributors 15
Preface 17
1: The Basic Tools and Terminology of Spine Treatment 19
1.1 Introduction 19
1.2 Which Way Is Up? 23
1.3 The Spine 24
1.4 Overview of the Handbook 26
1.5 Acknowledgments 27
1.6 References 27
2: Synthetic Biomaterials for Spinal Applications 29
2.1 Introduction 29
2.2 Mechanical Properties and Mechanical Testing 30
2.3 Metals and Metal Alloys 35
2.4 Ceramics 40
2.5 Polymers 42
2.6 Composites 44
2.7 Biological Effects 45
2.8 Biocompatibility Testing 48
2.9 Summary and Conclusions 49
2.10 References 50
3: Structure and Properties of Soft Tissues in the Spine 53
3.1 Introduction 53
3.2 Intervertebral Discs 54
3.3 Intervertebral Disc Aging and Degeneration 64
3.4 Ligaments 69
3.5 Spinal Cord 71
3.6 Conclusions 74
3.7 References 74
3.8 Review Questions 78
4: Biomechanics of Vertebral Bone 81
4.1 Introduction 81
4.2 Trabecular Bone 82
4.3 Mechanical Behavior of the Vertebral Body 92
4.4 Noninvasive Vertebral Strength Assessment 104
4.5 Acknowledgments 107
4.6 References 108
5: Musculature Actuation and Biomechanics of the Spine 117
5.1 Spine Muscles 117
5.2 Spinal Loading Estimation Techniques 122
5.3 Spinal Loads During Various Activities 140
5.4 References 157
6: Spine Disorders: Implications for Bioengineers 163
6.1 Introduction 163
6.2 Scoliosis 164
6.3 Osteoporosis 177
6.4 Cancer: Metastatic Spine Tumor 180
6.5 Rheumatoid Arthritis 181
6.6 Trauma: Whiplash Injury 184
6.7 References 190
7: Historical Review of Spinal Instrumentation for Fusion: Rods, Plates, Screws, and Cages 201
7.1 Thoraco Lumbar and Lumbo-Sacral 201
7.2 Anterior Instrumentation 209
7.3 Intervertebral Body Cages: Cervical and Lumbar 212
7.4 Cervical 214
7.5 Summary 221
7.6 Acknowledgments 221
7.7 References 221
8: Clinical Performance of Rods, Plates, Screws, and Cages 227
8.1 Introduction 227
8.2 Anterior Applications 229
8.3 Posterior Systems: Rods and Screws 233
8.4 Intervertebral Body Devices: Cages 248
8.5 Conclusions 251
8.6 Acknowledgments 251
8.7 References 251
9: Biologics to Promote Spinal Fusion 259
9.1 Introduction 259
9.2 Osteoinductive Bone Graft Substitutes 260
9.3 Bone Morphogenetic Proteins 261
9.4 Demineralized Bone Matrix 262
9.5 DBM: Pre-clinical Studies 265
9.6 DBM: Clinical Investigations 267
9.7 rhBMP-7 (rhOP-1): Preclinical Studies 270
9.8 rhBMP-7 (rhOP-1): Clinical Investigations 271
9.9 rhBMP-2 (INFUSE): Pre-clinical Studies 272
9.10 rhBMP-2 (INFUSE): Clinical Investigations 274
9.11 Calcium Sulfate 277
9.12 Hydroxyapatite 279
9.13 Tricalcium Phosphates 280
9.14 Biphasic Calcium Phosphate (BCP) 281
9.15 Calcium Phosphate/Collagen Composite Matrices 282
9.16 Conclusions 287
9.17 References 288
10: Nucleus Replacement of the Intervertebral Disc 299
10.1 Introduction 299
10.2 Intervertebral Disc 300
10.3 Degenerative Disc Disease: Etiology 300
10.4 Current Treatments for Degenerative Disc Disease 301
10.5 Total Disc Replacement 303
10.6 Nucleus Pulposus Replacement 303
10.7 Historical Design Perspective 309
10.8 Recent Design Concepts 311
10.9 Future Directions 316
10.10 References 318
11: Total Disc Arthroplasty 321
11.1 Introduction 321
11.2 Pioneers of Total Disc Arthroplasty 323
11.3 Contemporary Lumbar Disc Replacements 348
11.4 Cervical TDRs 361
11.5 Many Unanswered Questions Remain 380
11.6 Acknowledgments 382
11.7 References 382
12: Vertebral Compression Fracture Treatments 389
12.1 Vertebral Body Compression Fractures: The Clinical Problem 389
12.2 Nonoperative Care of VCFs 390
12.3 Vertebroplasty 392
12.4 Balloon Kyphoplasty 395
12.5 Bone Fillers 398
12.6 Calcium Cements 401
12.7 PMMA and the Potential for Adjacent Fracture 403
12.8 Conclusions 406
12.9 References 406
13: Standard Test Methods for Spine Implants 415
13.1 Introduction 415
13.2 Using Testing Standards 416
13.3 Terminology (ASTM F1582) 422
13.4 Standards for Fusion Systems 422
13.5 Standards for Intervertebral Body Fusion Devices (Cages) 432
13.6 Standards for Total Disc Replacements 438
13.7 Other Nonfusion Devices 443
13.8 Controversies and Challenges 444
13.9 Conclusions 457
13.10 References 457
14: Finite Element Modeling of the Spine 461
14.1 Introduction to the Finite Element Method 461
14.2 Application of the Finite Element Method to the Spine 463
14.3 In Search of a Better Model 465
14.4 Current Numerical Models of the Spine 472
14.5 Simulating Pathological and Post-surgical Biomechanics of the Spine 476
14.6 Looking Forward 479
14.7 Acknowledgments 480
14.8 References 480
15: FDA Regulation of Spinal Implants 491
15.1 Introduction 491
15.2 Overview of FDA Regulatory Framework 492
15.3 Overview of Product Clearance Pathways for Biologics and Drugs 507
15.4 FDA Regulation of Specific Types of Spinal Implants 513
15.5 Current Trends in the Regulation of Spinal Implants 520
15.6 References 525
16: Economics and Reimbursement for Spine Technologies 527
16.1 Introduction to Health Economics and Cost Analyses 527
16.2 What Do We Know About the Economics of Spine Technologies? 533
16.3 Conclusions 542
16.4 References 543
Index 547

Produkt-Details

• Erscheint lt. Verlag: 24.8.2006
• Sprache: englisch
• Themenwelt: Medizinische Fachgebiete ► Chirurgie ► Unfallchirurgie / Orthopädie
• Themenwelt: Medizin / Pharmazie ► Physiotherapie / Ergotherapie ► Orthopädie
• Themenwelt: Naturwissenschaften ► Chemie
• Themenwelt: Technik ► Bauwesen
• Themenwelt: Technik ► Maschinenbau
• Themenwelt: Technik ► Medizintechnik
• ISBN-10: 0-08-045937-4 / 0080459374
• ISBN-13: 978-0-08-045937-0 / 9780080459370