Microfluidic Technologies for Miniaturized Analysis Systems (eBook)

Steffen Hardt, Friedhelm Schonfeld (Herausgeber)

eBook Download: PDF

2007 | 2007
XXI, 616 Seiten
Springer US (Verlag)
978-0-387-68424-6 (ISBN)

Infos

This book addresses Lab-on-a-Chip devices. It focuses on microfluidic technologies that have emerged in the past decade. Coverage presents a comprehensive listing of the most promising microfluidic technologies in the Lab-on-a-Chip field. It also details technologies that can be viewed as toolboxes needed to set up complex Lab-on-a-Chip systems.

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Microfluidic Technologies for Miniaturized Analysis Systems provides a comprehensive overview of the fluidic aspects of Lab-on-a-Chip technology. This book describes the most important and state-of-the-art microfluidic technologies and the underlying principles utilized in the implementation of fluidic protocols of miniaturized analysis systems. This book discusses many of the effects, outcomes, and techniques which are unique to microfluidic systems. The specific components of this technology toolbox are elucidated through research and examples presented by some of the most renowned experts in the field.Microfluidic Technologies for Miniaturized Analysis Systems is an important reference for professionals and academic researchers seeking information about the latest techniques, including:Control and pumping of small amounts of liquidParticle and cell manipulationMicromixingSeparation technologyBioanalytic methods About the MEMS Reference Shelf:The MEMS Reference Shelf is a series devoted to Micro-Electro-Mechanical Systems (MEMS), which combine mechanical, optical, or fluidic elements on a common microfabricated substrate to create sensors, actuators, and microsystems. This series strives to provide a framework where basic principles, known methodologies, and new applications are integrated in a coherent and consistent manner.STEPHEN D. SENTURIA, MASSACHUSETTS INSTITUTE OF TECHNOLOGY,PROFESSOR OF ELECTRICAL ENGINEERING, EMERITUS

Inhalt

Preface 6
Table of Contents 9
List of Contributors 19
Chapter 1 Microfluidics: Fundamentals and Engineering Concepts 22
1. Introduction 22
2. Essentials of Fluidic Transport Phenomena at Small Scales 24
3. Scaling Analysis 35
4. System/Engineering Concepts and Design Approaches for Microfluidics 52
References 70
Chapter 2 Electrohydrodynamic and Magnetohydrodynamic Micropumps 80
1. Introduction 80
2. Electric Forces in the Bulk: Injection, Conduction, and Induction EHD Pumps 87
3. Electric Forces in the Diffuse Layer: Electroosmotic and AC/ IC Electroosmotic Pumps 106
4. Magnetic Forces: DC and AC MHD Pumps 120
5. Comparisons and Conclusions 128
Acknowledgments 132
References 132
Chapter 3 Mixing in Microscale 138
1. Introduction 138
2. Mass Transport in Microscale 139
3. Micromixers Based on Molecular Diffusion 146
4. Micromixers Based on Chaotic Advection 160
5. Active Micromixers 167
References 170
Chapter 4 Control of Liquids by Surface Energies 177
1. Introduction 177
2. Capillary Model 179
3. Plane Substrates with Wettability Patterns 184
4. Wetting of Topographically Patterned Substrates 201
5. Summary and Outlook 216
Acknowledgment 217
References 217
Chapter 5 Electrowetting: Thermodynamic Foundation and Application to Microdevices 223
1. Introduction 223
2. Theoretical Background 225
3. Electrowetting and Its Recent Variations 240
4. Microfluidic Device Using Electrowetting 247
5. Summary 256
Acknowledgments 256
References 256
Chapter 6 Magnetic Beads in Microfluidic Systems – Towards New Analytical Applications 260
1. Introduction 260
2. Types of Magnetic Beads 261
3. Forces on Magnetic Beads 263
4. Magnetic Bead Separation 265
5. Magnetic Bead Transport 269
6. Magnetic Beads as Labels for Detection 272
7. Separation and Mixing Using Magnetic Supraparticle Structures 276
8. Magnetic Beads as Substrates for Bio-assays 277
9. Magnetic Beads in Droplets 281
10. Conclusion 284
Acknowledgements 285
References 285
Chapter 7 Manipulation of Microobjects by Optical Tweezers 294
1. Introduction 294
2. Single-Particle Manipulation with a Focused Laser Beam 295
3. Multiparticle Manipulation Techniques 307
4. Optically Driven Microfluidic Components 316
5. Bio-manipulation Based on Optical Tweezers 324
6. Conclusions and Outlook 328
References 328
Chapter 8 Dielectrophoretic Microfluidics 334
1. Introduction 334
2. Quantification of Dielectrophoretic Micro-Fluidics 335
3. Microfluidic Applications of Dielectrophoresis 348
4. Conclusion 369
References 370
Chapter 9 Ultrasonic Particle Manipulation 375
1. Introduction 375
2. Theory 376
3. Transduction Techniques 386
4. Applications of Ultrasonic Particle Manipulation 391
5. The Future of Ultrasonic Particle Manipulation 401
Acknowledgement 401
References 401
Chapter 10 Electrophoresis in Microfluidic Systems 411
1. Introduction 411
2. Electrophoresis in Microfabricated Systems 414
3. Applications of Microchip Electrophoresis 425
4. Summary and Outlook 432
References 433
Chapter 11 Chromatography in Microstructures 457
1. Introduction 457
2. Examples of Chromatography on Microchips 463
3. Conclusions 483
References 484
Chapter 12 Microscale Field-Flow Fractionation: Theory and Practice 488
1. Introduction 488
2. Background and Theory 489
3. Miniaturization Effects in FFF 497
4. Microscale Electrical FFF 502
5. Microscale Cyclical Electrical FFF 511
6. Microscale Dielectrophoretic FFF 518
7. Microscale Thermal FFF 522
8. Miniaturized Flow FFF 524
9. Microscale Acoustic FFF 525
10. Other Microscale FFF Efforts 526
11. Nanoscale FFF 530
12. Conclusion 532
Acknowledgements 533
References 533
Chapter 13 Nucleic Acid Amplification in Microsystems 539
1. General Elements of Amplification 539
2. Micro–Macro Comparison 542
3. Microfluidic Realization Methods 546
4. Alternative Protocols to PCR 567
5 . Conclusion 570
References 571
Chapter 14 Cytometry on Microfluidic Chips 584
1. Introduction 584
2. Design of Microfluidic Flow Cytometers 587
3. Detection Concepts for Ultrasensitive Cytometry 595
4. Perspectives for Biotechnology 607
5. Conclusion 613
References 613
Index 621
ABOUT THE COVER 630

Produkt-Details

• Erscheint lt. Verlag: 29.9.2007
• Reihe/Serie: MEMS Reference Shelf
• Zusatzinfo: XXI, 616 p.
• Verlagsort: New York
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Pflege
• Themenwelt: Medizin / Pharmazie ► Physiotherapie / Ergotherapie ► Orthopädie
• Themenwelt: Naturwissenschaften ► Biologie
• Themenwelt: Naturwissenschaften ► Physik / Astronomie
• Themenwelt: Technik ► Bauwesen
• Themenwelt: Technik ► Elektrotechnik / Energietechnik
• Themenwelt: Technik ► Maschinenbau
• Themenwelt: Technik ► Medizintechnik
• Schlagworte: Analysis • Integrated circuit • Microfluidic • microfluidics • Miniaturized • Schönfeld • Schoenfeld • Schonfeld • Schönfeld • Stent • Systems • Technologies
• ISBN-10: 0-387-68424-7 / 0387684247
• ISBN-13: 978-0-387-68424-6 / 9780387684246