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Meningiomas (eBook)

Diagnosis, Treatment, and Outcome

Joung H. Lee (Herausgeber)

eBook Download: PDF
2008 | 2008
XXIII, 639 Seiten
Springer London (Verlag)
978-1-84628-784-8 (ISBN)

Lese- und Medienproben

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The overall incidence of meningiomas, particularly in the developed countries, is rising due to a growing size of the aging population, with people living longer and enjoying healthier lives than ever before. Additionally, an increased utilization of imaging studies such as computer tomography (CT) and magnetic resonance (MR) for routine evaluation of closed head injuries, paranasal sinus problems and various non-specific neurological symptoms, ranging from headaches to dizziness, has contributed to enhanced detection of incidental meningiomas.

The book contains the most up-to-date information in all matters related to meningiomas, and is written by multiple contributors - internationally recognized experts in their respective fields from Asia, USA and Europe.

This is an essential reference guide to neurosurgeons and neurologists (in training and in practice), as well as medical libraries, throughout the world.



Dr Joung H Lee is Director, Center for Neurofibromatosis and Benign Tumors, Brain Tumor Institute and Head, Section of Skull Base Surgery, Department of Neurosurgery at the Cleveland Clinic Foundation. He has published over 40 journal articles and guest-edited Neurosurgery Clinics of North America: Adjunct treatment modalities for skull base tumors. W.B. Saunders, October 2000.


Joung H. Lee has assembled a masterful volume on the diagnosis, treatment, and outcome of meningiomas. It is complete in that it covers all aspects of this tumor; every location is discussed by acknowledged experts and every technique is described in detail. Basic biology forms an important and up-to-date part of the text. This book will serve as a reference for many years; in particular, Dr. Lee feels surgeons and future patients will benefit. There is little question that these aims will be fulfilled in this important tour de force. John A. Jane, Sr. , MD, PhD Charlottesville, VA, USA vii Preface In planning this book, I had three major goals. The first was to compile and disseminate all the advances and new information relating to meningiomas which became available in the last 15-20 years. In this time frame, there has been a significant increase in our understanding in regards to the meningioma pathologic classification, the natural history and basic science. Dramatic technological advancements have also been made in diagnostic and interventional radiology as well as in surgical and radiation treatments for meningiomas, such as incorporation of the following in the treatment armamentaria: endoscopy, various skull base techniques, computer-assisted surgery and radiosurgery. Additionally, new information regarding surgical outcome and patient selection for surgery are becoming available, all of which are resulting in a significant change in how neurosurgeons treat patients with meningiomas. The second goal for this book was to teach and stimulate the next generation of neurosurgeons.

Dr Joung H Lee is Director, Center for Neurofibromatosis and Benign Tumors, Brain Tumor Institute and Head, Section of Skull Base Surgery, Department of Neurosurgery at the Cleveland Clinic Foundation. He has published over 40 journal articles and guest-edited Neurosurgery Clinics of North America: Adjunct treatment modalities for skull base tumors. W.B. Saunders, October 2000.

Foreword 6
Preface 7
Contents 9
Contributors List 14
I General Information 21
Meningiomas: Historical Perspective 22
Epidemiology 30
Human Meninges: Anatomy and Its Role in Meningioma Pathogenesis 34
Meninges: Embryology 44
Pathology of Meningiomas 49
Natural History, Growth Rates, and Recurrence 62
II Diagnostic Considerations 69
Diagnostic Neuroradiology: CT, MRI, fMRI, MRS, PET, and Octreotide SPECT 70
Meningiomas: Imaging Mimics 81
Preoperative Embolization of Meningiomas 102
Neuro-ophthalmic Evaluations in Patients with Meningiomas 113
III Basic Science 146
Meningioma Tumorigenesis: An Overview of Etiologic Factors 147
Molecular Basis of Meningioma Tumorigenesis and Progression 156
Meningiomas of the Central Neuraxis: Unique Tumors 165
Radiation- Induced Meningioma: Historical Perspective, Presentation, Management, and Genetics 171
Emerging Treatment Modalities I: Cyclooxygenase- 2 as a Therapeutic Target for Meningioma Tumor Growth 185
Emerging Treatment Modalities II: Gene Therapy for Meningiomas 192
IV Management and Outcome 207
Management Options and Surgical Principles: An Overview 208
Operative Outcome Following Meningioma Surgery: A Personal Experience of 600 Cases 213
Factors Influencing Outcome in Meningioma Surgery 217
The Novel “CLASS” Algorithmic Scale for Patient Selection in Meningioma Surgery 221
Endoscopy in Meningioma Surgery: Basic Principles, Applications, and Indications 226
Image-Guided Surgery for Meningiomas 234
Meningiomas and Epilepsy 246
Surgical Correction of Postoperative Strabismus 250
V Adjunct Treatment Modalities 254
Recent Advances in Therapeutic Radiation: An Overview 255
Conventional Radiation for Meningiomas 261
Gamma Knife Surgery for Meningiomas 268
Linear Accelerator Radiosurgery for Meningiomas 278
Brachytherapy for Meningiomas 283
Medical Therapy for Meningiomas 293
VI Meningiomas by Location: Special Considerations, Surgical Technique, Outcome, Complication Avoidance 299
Convexity Meningiomas 300
Parasagittal Meningiomas 307
Falcine Meningiomas 316
Olfactory Groove/Planum Sphenoidale Meningiomas 323
Tuberculum Sellae Meningiomas 329
Anterior Clinoidal Meningiomas 342
Optic Nerve Sheath Meningiomas I: Aggressive Surgical Management 350
Optic Nerve Sheath Meningiomas II: Conservative Management with Fractionated Stereotactic Radiotherapy 358
Lateral and Middle Sphenoid Wing Meningiomas 366
Orbitosphenoid Meningiomas 374
Cavernous Sinus Meningiomas: Conservative Surgical Management 384
Temporal Bone Meningiomas 388
Posterior Clinoidal Meningiomas 394
Petroclival and Upper Clival Meningiomas I: An Overview of Surgical Approaches 398
Petroclival and Upper Clival Meningiomas II: Anterior Transpetrosal Approach 410
Petroclival and Upper Clival Meningiomas III: Combined Anterior and Posterior Approach 419
Petrous Meningiomas I: An Overview 427
Petrous Meningiomas II: Ventral, Posterior and Superior Subtypes 436
Foramen Magnum Meningiomas 441
Cerebellar Convexity Meningiomas 449
Tentorial Meningiomas 456
Torcular, Transverse, and Sigmoid Sinus Meningiomas 464
Falcotentorial and Pineal Region Meningiomas 475
Intraventricular Meningiomas 485
Jugular Foramen Meningiomas I 505
Jugular Foramen Meningiomas II: An Otologist’s Approach, Perspective, and Experience 511
Spinal Meningiomas 519
VII Miscellaneous 530
Pediatric Meningiomas 531
NF2/Multiple Meningiomas 542
Peritumoral Edema 552
Primary Ectopic Meningiomas 559
Management of Arterial Encasement by Intracranial Meningiomas 570
Venous Reconstruction in the Management of Intracranial Meningiomas 587
Dural Reconstruction in Meningioma Surgery 602
Index 608

Erscheint lt. Verlag 11.12.2008
Zusatzinfo XXIII, 639 p.
Verlagsort London
Sprache englisch
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Allgemeinmedizin
Medizinische Fachgebiete Chirurgie Neurochirurgie
Medizin / Pharmazie Medizinische Fachgebiete Neurologie
Medizin / Pharmazie Medizinische Fachgebiete Onkologie
Schlagworte Age • aging • Brachytherapy • Endoscopy • Imaging • Meningiomas • radiosurgery • radiotherapy • Strabismus • Surgery
ISBN-10 1-84628-784-7 / 1846287847
ISBN-13 978-1-84628-784-8 / 9781846287848
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