Primary Optic Nerve Sheath Meningioma (eBook)

Branislav Jeremic, Susanne Pitz (Herausgeber)

eBook Download: PDF

2008 | 2008
XII, 139 Seiten
Springer Berlin (Verlag)
978-3-540-77558-4 (ISBN)

Infos

Optic nerve sheath meningioma (ONSM) is a rare tumour. Cases are usually separated into primary ONSM, which arises either intraorbitally or, less commonly, intracanalicularly, and secondary ONSM, which arises intracranially and subsequently invades the optic canal and orbit. This is the first book to cover all important aspects of the diagnosis and treatment of primary ONSM. After a general introduction, individual chapters discuss the clinical presentation, clinical examination and diagnosis, imaging, and histology. Treatment options are then addressed in detail, with special emphasis on external beam radiation therapy, and in particular stereotactic fractionated radiation therapy. The latter has recently produced consistently good results and is now considered the emerging treatment of choice for the vast majority of patients with primary ONSM. This well-illustrated book will prove invaluable to all practitioners who encounter primary ONSM in their clinical work.

Inhalt

DEDICATION 5
Foreword 7
Preface 9
Contents 11
Overall Introduction, Problem Definition, Incidence 13
Introduction 13
Incidence 16
Clinical Presentation 19
Introduction 19
Typical Presentation 20
Atypical Clinical Presentation 25
Clinical Evaluation of Primary Optic Nerve Sheath Meningioma 29
Introduction 30
Meningioma of the Optic Nerve and Orbit 30
Epidemiology 31
Special Cases 40
Differential Diagnosis 42
A Suggested Approach to Clinical Evaluation 45
Imaging Diagnosis of the Optic Nerve Sheath Meningioma 51
Introduction 51
Clinical Presentation 52
Imaging Features 52
Special Situations 58
Differential Diagnosis of Optic Nerve Enlargement 58
Miscellaneous 63
Histology and Molecular Genetics 67
Incidence and Epidemiology 67
Histological Classification 68
Meningioma Genetics 72
Surgery in Primary Optic Nerve Sheath Meningioma 79
Introduction 80
treatment Goals 80
A Subset of Data on Surgery in Primary ONSM 80
General Indications for Surgical Intervention 82
Canalicular Involvement 87
Conclusion 87
Conventional Radiation therapy in Primary Optic Nerve Sheath Meningioma 89
Postoperative Radiation Therapy 89
Exclusive Conventional Radiation therapy 92
3D Conformal RT 97
Introduction 97
Principles and techniques of 3D Conformal Rt 98
Literature on 3D Conformal Rt for ONSM 102
Treatment Related Toxicity 105
Intensity Modulated Radiotherapy for Optic Nerve Sheath Meningioma 107
Introduction 107
Radiobiological Considerations: Radiation Dose and Fractionation 108
Complications 109
Contraindications to Radiotherapy 110
Intensity Modulated Radiotherapy 110
Stereotactic Radiation therapy in Primary Optic Nerve Sheath Meningioma 117
Introduction 117
Stereotactic Radiosurgery 118
Stereotactic Fractionated Radiation therapy 119
Subject Index 141
List of Contributors 145

Produkt-Details

• Erscheint lt. Verlag: 19.8.2008
• Reihe/Serie: Medical Radiology
• Reihe/Serie: Radiation Oncology
• Vorwort: Luther W. Brady, Hans-Peter Heilmann, Michael Molls, Carsten Nieder
• Zusatzinfo: XII, 139 p.
• Verlagsort: Berlin
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Allgemeines / Lexika
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Augenheilkunde
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Chirurgie
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
• Themenwelt: Medizinische Fachgebiete ► Radiologie / Bildgebende Verfahren ► Radiologie
• Schlagworte: Diagnosis • Genetics • Histology • Imaging • Magnetic Resonance Imaging • Magnetic Resonance Imaging (MRI) • molecular genetics • optic nerve sheath meningioma • Radiation • radiation therapy • radiotherapy • stereotactic radiation therapy • Surgery • Tumor
• ISBN-10: 3-540-77558-7 / 3540775587
• ISBN-13: 978-3-540-77558-4 / 9783540775584