Chiral Drugs – Chemistry and Biological Action

GQ Lin (Autor)

Software / Digital Media

472 Seiten

2011
John Wiley & Sons Inc (Hersteller)
978-1-118-07564-7 (ISBN)

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Presenting an overview of chiral drugs and their impact on the pharmaceutical industry, Chiral Drugs: Chemistry and Biological Action provides an integrated perspective of chiral drugs from concept, synthesis, and pharmaceutical properties. The book includes important chiral technologies and reviews of 200 chiral drugs that have either been approved or made it to advanced trials. It's interdisciplinary approach combines synthetic organic chemistry, medicinal chemistry, and pharmacology in a way that fosters cooperation among interdisciplinary scientists and researchers in both academia and the pharma or biotech industries.

GUO-QIANG LIN, is a professor at the Shanghai Institute of Organic Chemistry and an adjunct professor at Fudan University, China. He is the Director of the Division of Chemical Science of the National Natural Science Foundation of China. Among Professor Lin's publications are the Wiley books Principles and Applications of Asymmetric Synthesis and Biocatalysis for the Pharmaceutical Industry. QI-DONG YOU, PHD, is the Dean and a professor of the School of Pharmacy at China Pharmaceutical University. He is an Associate Editor of Progress in Pharmaceutical Sciences and serves on the Editorial Board of the International Journal of Medicinal Chemistry and Acta Pharmaceutica Sinica. Dr. You is a coauthor of over eighty publications, and an inventor or co-inventor of over twenty patent applications and patents. JIE-FEI CHENG, PHD, is the Director of Otsuka Shanghai Research Institute, a fully owned subsidiary of Otsuka Pharmaceutical Co., Ltd Japan. Formerly an associate professor at Shanghai Institute of Organic Chemistry, he has worked for over fifteen years in the pharmaceutical and biotech industries in the United States. Dr. Cheng is a coauthor of over fifty peer-reviewed publications, and an inventor or coinventor of over twenty patent applications and patents.

ABOUT THE EDITORS vii CONTRIBUTORS ix INTRODUCTION 1 1 OVERVIEW OF CHIRALITY AND CHIRAL DRUGS 3 Guo-Qiang Lin, Jian-Ge Zhang, and Jie-Fei Cheng 2 CHIRAL DRUGS THROUGH ASYMMETRIC SYNTHESIS 29 Guo-Qiang Lin and Xing-Wen Sun 3 CHIRAL DRUGS VIA BIOCATALYTICAL APPROACHES 77 Jianqiang Wang and Wenya Lu 4 RESOLUTION OF CHIRAL DRUGS 137 Qi-Dong You 5 FLUORINE-CONTAINING CHIRAL DRUGS 195 Xiao-Long Qiu, Xuyi Yue, and Feng-Ling Qing 6 INDUSTRIAL APPLICATION OF CHIRAL TECHNOLOGIES 253 Hui-Yin (Harry) Li, Rui Liu, Carl Behrens, and Chao-Ying Ni 7 STRUCTURAL BASIS AND COMPUTATIONAL MODELING OF CHIRAL DRUGS 297 Deping Wang and Eric Hu 8 PHARMACOLOGY OF CHIRAL DRUGS 323 Yongge Liu and Xiao-Hui Gu 9 PHARMACOKINETICS OF CHIRAL DRUGS 347 Hanqing Dong, Xiaochuan Guo and Zengbiao Li 10 TOXICOLOGY OF CHIRAL DRUGS 381 Guang Yang and Hai-Zhi Bu 11 REPRESENTATIVE CHIRAL DRUGS 401 Jiangqin Sun, Dingguo Liu, and Zhimin Wang INDEX 449

Verlagsort	New York
Sprache	englisch
Maße	150 x 250 mm
Gewicht	666 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete
	Medizin / Pharmazie ► Pflege
	Naturwissenschaften ► Chemie ► Organische Chemie
ISBN-10	1-118-07564-1 / 1118075641
ISBN-13	978-1-118-07564-7 / 9781118075647
Zustand	Neuware