Genetics of Colorectal Cancer

John D. Potter, Noralane M. Lindor (Herausgeber)

Buch | Softcover

309 Seiten

2010 | 1st ed. Softcover of orig. ed. 2009
Springer-Verlag New York Inc.
978-1-4419-1865-9 (ISBN)

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Genetic susceptibility refers to how variations in a person’s genes increase or decrease his or her susceptibility to environmental factors, such as chemicals, radiation and lifestyle (diet and smoking). This volume will explore the latest findings in the area of genetic susceptibility to gastrointestinal cancers, focusing on molecular epidemiology, DNA repair, and gene-environment interactions to identify factors that affect the incidence of GI cancers. Topics will include germline susceptibility, including Mendelian patterns of inheritance and gene-environment interactions that lead to cancer etiology.

Epidemiology and Models of Colorectal Cancer.- Colorectal Cancer: Epidemiology.- Mouse Models of Intestinal Cancer.- Pathways to Colorectal Cancer.- The Chromosomal-Instability Pathway and APC Gene Mutation in Colorectal Cancer.- DNA Methylation in Colorectal Cancer: Multiple Facets of Tumorigenesis.- Pathways and Pathology.- Germline Susceptibility – Mendelian and Other Syndromes.- Familial Adenomatous Polyposis.- DNA Mismatch Repair and Lynch Syndrome.- Additional Syndromes with Hereditary Predisposition to Colorectal Cancer.- Familial Colorectal Cancer Type X.- Families with Serrated Neoplasia of the Colon.- Peutz–Jeghers Syndrome.- Juvenile Polyposis.- BLM Mutation and Colorectal Cancer Susceptibility.- The Role of p53 in Colorectal Cancer.- Chromosomes 8q24 and 9p24: Associations with Colorectal Cancer.- Germline Susceptibility – Gene-Environment Interactions.- Genetic Variability in Folate-Mediated One-Carbon Metabolism and Risk of Colorectal Neoplasia.- Genetic Variability in NSAID Targets and NSAID-Metabolizing Enzymes and Colorectal Neoplasia.- The Role of Chemical Carcinogens and Their Biotransformation in Colorectal Cancer.- Calcium and Vitamin D.

Erscheint lt. Verlag	9.11.2010
Reihe/Serie	Cancer Genetics
Zusatzinfo	XI, 309 p.
Verlagsort	New York, NY
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizinische Fachgebiete ► Chirurgie ► Viszeralchirurgie
	Medizinische Fachgebiete ► Innere Medizin ► Gastroenterologie
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
	Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
	Studium ► Querschnittsbereiche ► Epidemiologie / Med. Biometrie
ISBN-10	1-4419-1865-5 / 1441918655
ISBN-13	978-1-4419-1865-9 / 9781441918659
Zustand	Neuware