Molecular Pathology of the Prions

Buch | Softcover

279 Seiten

2010 | 1st ed. Softcover of orig. ed. 2001
Humana Press Inc. (Verlag)
978-1-61737-252-0 (ISBN)

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Internationally recognized investigators review the latest developments in, and novel approaches to, understanding the prion protein and prion diseases at the molecular level. Utilizing a variety of cutting-edge techniques, these distinguished scientists seek to define the normal function of a prion protein, to detect and measure the early immune response to prion disease, and to discover possible therapeutic targets. They also use transgenic mice and new electrophysiological investigations to elucidate the pathogenetic mechanisms involved in prion diseases. State-of-the-art and richly insightful, Molecular Pathology of the Prions captures for basic and clinical neuropathologists the latest developments and approaches to understanding the pathogenesis of prion diseases, and by analogy suggests possible research techniques for the more common proteinopthies, such as Alzheimer's and Parkinson's diseases.

What Would Thomas Henry Huxley Have Made of Prion Diseases?.- Prion Protein as Copper-Binding Protein at the Synapse.- A Function for the Prion Protein?.- Prion Protein Peptide.- Characterization of Bovine Spongiform Encephalopathy and Scrapie Strains/Isolates by Immunochemical Analysis of PrPSc.- Differential Targeting of Neurons by Prion Strains.- Transgenic Studies of Prion Diseases.- Prions: From Neurografts to Neuroinvasion.- Cellular and Transgenic Models of Familial Prion Diseases.- Central Nervous System Inflammation and Prion Disease Pathogenesis.- The Electroneuropathology of Prion Disease.- Transmissible Spongiform Encephalopathy Neurobiology and Ultrastructure Suggests Extracellular PrPSc Conversion Consistent with Classical Amyloidosis.- Conformation as Therapeutic Target in the Prionoses and Other Neurodegenerative Conditions.- Prions of Yeast From Cytoplasmic Genes to Heritable Amyloidosis.

Erscheint lt. Verlag	9.11.2010
Reihe/Serie	Methods in Molecular Medicine ; 59
Zusatzinfo	XII, 279 p.
Verlagsort	Totowa, NJ
Sprache	englisch
Maße	152 x 229 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete
Themenwelt	Studium ► 2. Studienabschnitt (Klinik) ► Pathologie
ISBN-10	1-61737-252-8 / 1617372528
ISBN-13	978-1-61737-252-0 / 9781617372520
Zustand	Neuware