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Contemporary Topics in Immunobiology

Buch | Hardcover

202 Seiten

1972
Kluwer Academic/Plenum Publishers (Verlag)
978-0-306-37801-0 (ISBN)

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Investigators, teachers, and practitioners in the biomedical sciences are keenly aware of the current crisis in scientific communications. With well over a thousand biomedical journals producing new issues each month, and with approximately five hundred new technical books in biomedicine being 1 published each year, not to mention the proliferation of information-ex- change meetings, it is all too clear that we are in danger of being inundated by a flood of tables, figures, and hypotheses. The problem is particularly acute in immunology, as the rate of information production is increasing geometrically, and immunological approaches have been extended into other biological and medical fields to further diversify the research over a vast literature. Abstracting and information-retrieval services do much to improve the investigator's lot, but do not offer solutions for one particularly distressing aspect of the crisis. In the midst of our informational overabundance, one often finds that interrelationships between an investigator's collective findings are becoming blurred, or that the relation of his total work to the field are not clear.
Although review articles are indispensable in fixing the status of a given problem, they do not provide the detailed attention to a single author's work that is needed.

1. Systems of Lymphocytes in Mouse and Man: An Interim Appraisal.- Choice of Working Materials.- In Vitro Systems.- In Vivo Methods.- Primary and Secondary Lymphoid Organs.- Development of the Lymphoid System: Precursor Cell Migrations.- Surface Antigen Changes.- Extrathymic Maturation.- T-Cell Pool and Recirculation.- Organ Distribution of T Cells.- B Cells.- A Working Hypothesis.- Methods of Quantitation of T Cells.- Autoregulation.- Internal Environmental Factors.- Endocrine Status.- Gut Flora.- External Environmental Factors.- Some Human Implications.- The Congenital Immune Deficiency States.- Lymphoid Neoplasia.- Hodgkin's Disease.- References.- 2. A Developmental Approach to the Biological Basis for Antibody Diversity.- Development of the Bursal Line of Cells in Chickens.- Theoretical Implications of Generation of Antibody Diversity Within the Bursa.- Conclusions.- References.- 3. The Mammalian "Bursa Equivalent": Does Lymphoid Differentiation Along Plasma Cell Lines Begin in the Gut-Associated Lymphoepithelial Tissues (GALT) of Mammals?.- Predictions in the GALT Theory.- Conclusions.- References.- 4. C3-Receptor Sites on Leukocytes: Possible Role in Opsonization and in the Immune Response.- Receptors for Immunoglobulin and Complement on Mouse Leukocytes.- Do Lymphocytes Specifically Recognize Antigen-Antibody Interactions?.- Cytotoxic Function of Lymphocytes.- Induction of DNA Synthesis in Normal Lymphocyte Cultures by Antigen-Antibody Complexes.- Antibody-Mediated Immune Suppression of the Immune Response In Vitro.- Presence of a Receptor for C3 on the Membrane of Certain Lymphocytes (CRL).- Complement Components Involved in the Interaction Between EAC and CRL.- Nature of the Receptor Site on CRL.- Specific Isolation of CRL: Properties of the Isolated Population of Cells.- Role of CRL in the Phenomenon of Follicular Localization of Antigen.- Enhancing Effect of Antibody Studied at the Antigenic Determinant Level.- Concluding Remarks.- Acknowledgment.- References.- 5. Surface Immunoglobulins on Lymphoid Cells.- Expression of V Gene in B Lymphocytes.- Expression of V Gene in T Lymphocytes.- Blocking of ABC by Anti-Immunoglobulin Sera.- Blocking of Functional Activities of T Lymphocytes.- Blocking of Functional Activities of B Lymphocytes.- Direct Binding of Anti-Immunoglobulins to B Lymphocytes.- Direct Binding of Anti-Immunoglobulins to T Lymphocytes.- Synthesis of Immunoglobulins by B and T Cells.- Immunoglobulin Gene Expression in Lymphoid Cell Differentiation.- Acknowledgments.- References.- 6. Cellular Basis of Immunological Unresponsiveness.- Induction of Unresponsiveness with Heterologous Serum Proteins.- Kinetics of Induction of Immunological Unresponsiveness.- In Vitro Studies.- In Vivo Studies.- Relationship Between Antibody Formation and the Induction Process of Unresponsiveness.- Adult Mice Rendered Unresponsive to HGG.- Newborn Rabbits Rendered Unresponsive to BSA.- Adult Rabbits Rendered Unresponsive to BSA.- Cellular Sites of Immunological Unresponsiveness.- Macrophages.- Thymus-Derived and Bone Marrow-Derived Cells.- Termination of Immunological Unresponsiveness.- References.- 7. Application of Marrow Grafts in Human Disease: Its Problems and Potential.- Failure of the Pluripotential Cell (P Cell).- Failure of the Immune System (L Cell).- Failure of the Hematopoietic System (H Cell).- Marrow Transplantation as a Prelude to Organ Grafting.- Marrow Transplantation in the Treatment of Malignancy.- Use of Syngeneic Marrow Where Tumor-Specific Antigens Are Weak or in Doubt.- Use of Syngeneic Marrow Where Strong Tumor Antigens Exist or Are Suspected.- Use of Allogeneic Marrow with Histoincompatible Donors.- Use of Allogeneic Marrow with Histocompatible Grafts.- Preparation of Recipients for Marrow Grafting.- Problems Related to the Presensitized State.- GVH Disease.- Conclusions.- References.

Zusatzinfo	biography
Sprache	englisch
Maße	150 x 230 mm
Themenwelt	Studium ► 2. Studienabschnitt (Klinik) ► Pathologie
Themenwelt	Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
ISBN-10	0-306-37801-9 / 0306378019
ISBN-13	978-0-306-37801-0 / 9780306378010
Zustand	Neuware