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Cellular Senescence and Tumor Suppression

Peter D. Adams, John M. Sedivy (Herausgeber)

Buch | Hardcover

272 Seiten

2009 | 2010 ed.
Springer-Verlag New York Inc.
978-1-4419-1074-5 (ISBN)

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As cells mature they naturally stop dividing and enter a period called senescence. Cellular senescence, a growth-arrest program that limits the lifespan of mammalian cells and prevents unlimited cell proliferation, is attracting considerable interest because of its links to tumor suppression.

As cells mature they naturally stop dividing and enter a period called senescence. But cellular senescence can also be induced prematurely by certain oncogenes involved in cancer development. Cellular senescence, a growth-arrest program that limits the lifespan of mammalian cells and prevents unlimited cell proliferation, is attracting considerable interest because of its links to tumor suppression.

Senescence signals.- Telomere Biology and Biochemistry.- Role of RecQ Helicases in Nuclear DNA Repair and Telomere Maintenance.- Oncogene-Induced Senescence (OIS) as a Cellular Response to Oncogenic Stresses.- Stress-Induced Senescence.- The senescent phenotype.- The Secretome of Senescent Cells.- Chromatin Structure in Senescent Cells.- A Comparison of Senescence in Mouse and Human Cells.- The physiological consequences of senescence.- Replicative Senescence as an Intrinsic Tumor-Suppressor Mechanism.- Telomere Dysfunction and Senescence in Stem Cell and Tissues Aging.- Mining Cellular Senescence for Drug Targets.

Zusatzinfo	XIII, 272 p. With 1 4-color insert.
Verlagsort	New York, NY
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
ISBN-10	1-4419-1074-3 / 1441910743
ISBN-13	978-1-4419-1074-5 / 9781441910745
Zustand	Neuware