Gene Silencing

New Research

Buch | Hardcover

201 Seiten

2006
Nova Biomedical (Verlag)
9781594548321 (ISBN)

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Gene silencing is a general term describing epigenetic processes of gene regulation. The term gene silencing is generally used to describe the 'switching off' of a gene by a mechanism other than genetic mutation. Genes are regulated at either the transcriptional or post-transcriptional level. This book presents the research in this field.

Gene silencing is a general term describing epigenetic processes of gene regulation. The term gene silencing is generally used to describe the 'switching off' of a gene by a mechanism other than genetic mutation. That is, a gene which would be expressed (turned on) under normal circumstances, is switched off by machinery in the cell. Genes are regulated at either the transcriptional or post-transcriptional level. Transcriptional gene silencing is the result of histone modifications, creating an environment of heterochromatin around a gene that makes it inaccessible to transcriptional machinery (RNA polymerase, transcription factors, etc.). Post-transcriptional gene silencing is the result of mRNA of a particular gene being destroyed. The destruction of the mRNA prevents translation to form an active gene product (in most cases, a protein). A common mechanism of post-transcriptional gene silencing is RNAi. Both transcriptional and post-transcriptional gene silencing are used to regulate endogenous genes. This book presents the latest research in this important field.

Preface; High Frequent Gene Silencing of Hemetopoietic Cell Specific Protein Tyrosinephosphatase SHP1 in Hemetopoietic Cell Malignancies; Age Management Treatments Which Target Silenced Genes; Gene Silencing in Tumours: The Role of the Ras Association Domain Family 1 Gene in Carcinogenesis ; Human DNA cis-Elements Protecting the VHL Promoter and CpG Island from Methylation are Functional in the Mouse; Intron-Mediated Gene Silencing; DNA Methylation and Epigenetic Gene Silencing in Breast Cancer; Index.

Erscheint lt. Verlag	1.4.2006
Zusatzinfo	Illustrations
Sprache	englisch
Maße	260 x 180 mm
Gewicht	594 g
Themenwelt	Informatik ► Weitere Themen ► Bioinformatik
	Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
ISBN-13	9781594548321 / 9781594548321
Zustand	Neuware