The Implicit Genome
Oxford University Press Inc (Verlag)
978-0-19-517271-3 (ISBN)
Most analyses assume that genomes are to be read as linear text, much as a sequence of nucleotides can be translated into a sequence of amino acids by looking in a table. However, information can evolve in genomes with distinct forms of representation, such as in the structure of DNA or RNA and/or the relationship between nucleotide sequences. Such information has importance to biology yet is largely unexpected and unexplored. As described in this volume, much of this information, through mechanisms ranging from alternative splicing of RNA to the generation of bacterial coat protein diversity, affects the probability of distinct types of alterations in the nucleic acid sequence. Some genomic DNA sequences affect genome stability, handling and organization, with implications for the robustness of lineages over evolutionary time. The examples reviewed in this volume, taken from a broad range of biological organisms, both extend our view of the nature of information encoded within genomes, and can deepen our appreciation of the power of natural selection, through which this information, in its various forms, has emerged.
Dr. Lynn Helena Caporale received her Ph.D. in Molecular Biology from the University of California at Berkeley and is the author of Darwin and the Genome. She is the Associate Director for Comparative Genomics at the Judith P. Sulzberger Genome Center at Columbia University.
Lynn Helena Caporale: An Overview of the Implicit Genome
1: Donald M. Crothers: Sequence-Dependent Properties of DNA and Their Role in Function
2: Errol C. Friedberg: Mutation as a Phenotype
3: Christopher D. Bayliss and E. Richard Moxon: Repeats and Variation in Pathogen Selection
4: David G. King, Edward N. Trifonov, Yechezkel Kashi: 4. Tuning Knobs in the Genome: Evolution of Simple Sequence Repeats by Indirect Selection
5: J. Dave Barry: Implicit Information in Eukaryotic Pathogens as the Basis of Antigenic Variation
6: Eduardo P. C. Rocha: The Role of Repeat Sequences in Bacterial Genetic Adaptation to Stress
7: Gary Myers, Ian Paulsen, and Claire Fraser: The Role of Mobile DNA in the Evolution of Prokaryotic Genomes
8: Susan R. Wessler: Eukaryotic Transposable Elements: Teaching Old Genomes New Tricks
9: Ellen Hsu: Immunoglobulin Recombination Signal Sequences: Somatic and Evolutionary Functions
10: Rupert Beale and Dagmer Iber: Somatic Evolution and Antibody Genes
11: Nancy Maizels: Regulated and Unregulated Recombination of G-rich Genomic Regions
12: Rhona H. Borts and David T. Kirkpatrick: The Role of the Genome in the Initiation of Meiotic Recombination
13: Carolyn L. Jahn: Nuclear Duality and the Genesis of Unusual Genomes in Ciliated Protozoa
14: Harold C. Smith: Editing Informational Content of Expressed DNA Sequences and Their Transcripts
15: Brenton R. Graveley: Alternative Splicing: One Gene, Many Products
16: Alyson Ashe and Emma Whitelaw: Imprinting: the Hidden Genome
John Doyle, Marie Csete, and Lynn Caporale: Epilogue: An Engineering Perspective: The Implicit Protocols
References
| Erscheint lt. Verlag | 23.2.2006 |
|---|---|
| Zusatzinfo | 80 line drawings |
| Verlagsort | New York |
| Sprache | englisch |
| Maße | 234 x 155 mm |
| Gewicht | 576 g |
| Themenwelt | Informatik ► Weitere Themen ► Bioinformatik |
| Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie | |
| ISBN-10 | 0-19-517271-X / 019517271X |
| ISBN-13 | 978-0-19-517271-3 / 9780195172713 |
| Zustand | Neuware |
| Informationen gemäß Produktsicherheitsverordnung (GPSR) | |
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