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Protein Misfolding in Neurodegenerative Diseases

Neha Gogia, Sandeep Kumar Singh, Vidyadhara Devarunda Jaganath (Autoren)

Buch | Softcover

574 Seiten

2025
Academic Press Inc (Verlag)
978-0-443-18716-2 (ISBN)

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Protein Misfolding in Neurodegenerative Diseases is a comprehensive review of proteome homeostasis in neurons, and in the brain. Beginning with an introduction on factors involved in the formation and aggregation of misfolded proteins, chapters then discuss the precise cellular and molecular mechanisms involved in these processes and their role in neurodegeneration and disease. Additional topics of focus include protein clearance mechanisms like protein quality control, disease-modifiers, molecular druggable targets, novel therapeutics, and emerging techniques that block or delay disease onset or progression. This volume is relevant for researchers working with neurodegenerative diseases, including Alzheimer's disease, Parkinson’s disease, ALS, Creutzfeldt-Jakob disease, and more.

Dr. Gogia is a Post-Doctoral Associate at Yale. Having completed her PhD degree at the University of Dayton, and Cornell University’s International Agriculture and Rural Development Program (IARD) she was awarded the Gerald L. Willis Award of Excellence for Outstanding Teaching in 2019. Her current work focuses on understanding cellular and molecular mechanisms underlying polyglutamine diseases, namely the identification and validation of genetic modifiers which can serve as potential therapeutic targets and can ameliorate the onset or progression of neurodegenerative diseases. Dr. Sandeep Kumar Singh holds a PhD in Biotechnology and is an Assistant Professor of Medical Biotechnology at the All India Institute of Medical Sciences (AIIMS), Nagpur, Maharashtra, India. With nearly a decade of research experience, including a postdoctoral tenure in the Department of Neurobiology at The University of Chicago, his expertise spans molecular and cellular neuroscience. Vidyadhara Devarunda Jaganath works in the Department of Neurology and Neuroscience, Yale University School of Medicine, CT, USA.

1. Maintenance of balanced proteome homeostasis
2. Determinants of protein misfolding, aggregation in neuronal cell death
3. Classification, structure, and function of protein aggregates in proteinopathies
4. Protein aggregation and cellular and molecular mechanisms in neurodegenerative disease
5. Advances in methods to detect and study protein aggregation
6. Organelle specific protein quality control
7. Molecular chaperones and co-chaperones in proteostasis
8. The ubiquitin-Proteasome System (UPS) and Autophagy lysosomal proteolytic pathways
9. Alterations in protein quality control
10. Alternate mechanisms to maintain proteome homeostasis
11. Advances in developing novel therapeutics, strategies, approaches and use of emerging techniques
12. Challenges in translating laboratory findings to drug development
13. Advancements in drug delivery technologies for protein misfolding diseases

Erscheinungsdatum	10.04.2025
Verlagsort	San Diego
Sprache	englisch
Maße	152 x 229 mm
Gewicht	900 g
Themenwelt	Informatik ► Weitere Themen ► Bioinformatik
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie
	Studium ► 2. Studienabschnitt (Klinik) ► Pathologie
	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
	Naturwissenschaften ► Biologie ► Humanbiologie
	Naturwissenschaften ► Biologie ► Zoologie
ISBN-10	0-443-18716-9 / 0443187169
ISBN-13	978-0-443-18716-2 / 9780443187162
Zustand	Neuware