Twin and Family Studies of Epigenetics

Buch | Softcover

374 Seiten

2021
Academic Press Inc (Verlag)
978-0-12-820951-6 (ISBN)

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Twin and Family Studies of Epigenetics, Volume 27, the latest release in the Translational Epigenetics series, gathers expert opinions on epigenetic twin and family study research methods, recent findings across various disease areas, and future directions. The book provides in-depth coverage of epigenetics fundamentals, twin and family epigenetic study design, and the broader role of epigenetics in answering questions on the developmental origins of health and disease. Throughout the volume, twin and family studies are employed to examine causes of epigenetic variation, the relationship between epigenetic modifications and mental illness, cancers, cardiovascular disease, diabetes, obesity, high blood pressure, and more.

Emerging research methods applied in twin and family studies discussed include imaging epigenetics, exposure-specific DNA methylation changes, and unravelling time trends in epigenetic effects.

Dr Shuai Li has long-term experience in analyzing data from twin and family studies, including the novel epigenomic data. His PhD uses twin and family studies to research DNA methylation. He has published more than 10 papers on epigenetic epidemiological studies, specializing in twin and family designs. Professor John Hopper, AM, was one of the nine inaugural Australia Fellows awarded by NHMRC in 2007 and is currently a NHMRC Senior Principal Research Fellow. He is a Professorial Fellow with a PhD in Mathematical Statistics, and is currently Director (Research) of the Centre for Epidemiology and Biostatistics in the School of Population Global Health at The University of Melbourne. He has published more than 700 papers, specializing in the statistical methodology and its application for analyzing twin and family data, and addressing the genetic and environmental aetiology of diseases and health. He is principal or co-investigator on a number of case-control-family studies across a range of diseases and conditions, particularly breast cancer and colorectal cancer (both funded by the National Institutes of Health (USA)), prostate cancer, melanoma, childhood cancer and asthma. He is a co-investigator on several cohort studies, including Health 2020 and long term follow-up of the 1968 Tasmanian Asthma Study. Professor Hopper has been Director of the Australian Twin Registry (Now is Twins Research Australia) since 1990 and has been awarded a NHMRC CRE grant in Twin Research in 2014. Dr. Tollefsbol is a Distinguished Professor at the University of Alabama at Birmingham. He holds doctorates in molecular biology and osteopathic medicine, trained with National Academy of Science members and has over 200 peer-reviewed publications. Reports highlighting the translatability to the lay public of the discoveries made in his laboratory have appeared in international media representing >50 million readers. Dr. Tollefsbol has been featured as an Investigator in the Spotlight by the NIH as well as a Scientist in the Spotlight by ScienceNow. He is an Associate Editor for Frontiers in Genetics, a contributor to Lewin’s GENES classic textbook and Lead Editor for Elsevier’s Translational Epigenetics Series. Dr. Tollefsbol has been named a “Highly Ranked Scholar worldwide (ScholarGPS). He has been invited for numerous endowed keynote presentations, his research has been highlighted in eScience News and ScienceDaily and he has published 20 scholarly books on topics related to his research.

ART 1 Introduction
1. Value of twin and family study designs for epigenetic research
2. Evaluation and measurement of epigenetic modifications in population-based studies

PART 2 Human health applications
3. Discordant monozygotic twin studies of epigenetic mechanisms in mental health
4. DNA methylation and breast cancer risk: value of twin and family studies
5. Twin and family studies on epigenetics and oral health
6. Twin and family epigenetic studies of type 2 diabetes
7. Twin and family studies on epigenetics and obesity
8. DNA methylation and blood pressure in Chinese adult twins
9. Twin and family studies on epigenetics of autoimmune diseases
10. Twin studies on the epigenetics of selected neurological disorders and carotid artery disease
11. Disease-discordant twin studies of epigenetics and cancer
12. Sex differences in epigenetic profiles: The value of twin studies

PART 3 Emerging approach
13. Combining twin-family designs with measured genetic variants to study the causes of epigenetic variation
14. Imaging epigenetics and the radiogenomics
15. DNA methylation changes specific to environmental exposures: The strengths of twin studies using cigarette smoking as an example
16. Time trends in epigenetic signatures and population health risks
17. Ambient air pollution and human epigenetic modifications

Erscheinungsdatum	17.08.2021
Reihe/Serie	Translational Epigenetics
Mitarbeit	Herausgeber (Serie): Trygve O. Tollefsbol
Zusatzinfo	70 illustrations (30 in full color); Illustrations
Verlagsort	San Diego
Sprache	englisch
Maße	191 x 235 mm
Gewicht	750 g
Themenwelt	Informatik ► Weitere Themen ► Bioinformatik
Themenwelt	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
ISBN-10	0-12-820951-8 / 0128209518
ISBN-13	978-0-12-820951-6 / 9780128209516
Zustand	Neuware