Physiologically Based Pharmacokinetic (PBPK) Modeling
Academic Press Inc (Verlag)
978-0-12-818596-4 (ISBN)
Dr. Jeffrey Fisher is a research toxicologist with the U.S. Food and Drug Administration, National Center for Toxicological Research. He was formerly a Professor in the Department of Environmental Health Science, College of Public Health at the University of Georgia (UGA). He joined the University of Georgia in 2000 and served as Department Head of the Department of Environmental Health Sciences from 2000 to 2006 and Director of the Interdisciplinary Toxicology Program at UGA from 2006-2010. He spent most of his career at the Toxicology Laboratory, Wright Patterson AFB, where he was Principal Investigator and Senior Scientist in the Toxics Hazards Division and Technical Advisor for the Operational Toxicology Branch. Dr. Fisher has published over 170 papers on pharmacokinetics and PBPK modeling in laboratory animals and humans. He has served on several national panels and advisory boards for the DoD, ATSDR, USEPA and non-profit organizations. He was a U.S. delegate for the North Atlantic Treaty Organization. Dr. Fisher served on the International Life Sciences Institute Steering Committee, which evaluated chloroform and dichloroacetic acid using EPA-proposed Carcinogen Risk Guidelines. He is Past President of the Biological Modeling Specialty Section of the Society of Toxicology, reviewer for several toxicology journals, and was Co-Principal Investigator on a National Institutes of Health (NIH)-supported workshop on Mathematical Modeling at the University of Georgia in the fall of 2003. He was a member of the National Academy of Sciences subcommittee on Acute Exposure Guideline Levels (AEGLs) from 2004-2010 and Science Advisory Board for the US EPA (2007-2010). He is a fellow of the Academy of Toxicological Sciences and an associate editor for Toxicological Sciences. Dr. Fisher has a B.S. degree in biology from the University of Nebraska at Kearney, a M.S. degree in biology from Wright State University, and a Ph.D. in Zoology/Toxicology from Miami University. Dr. Jeffery M. Gearhart is a Senior Toxicologist with the Henry M. Jackson Foundation for Military Medicine, working in the United States Air Force School of Aerospace Medicine, Aeromedical Department, Wright-Patterson AFB. Dr. Gearhart also is an adjunct professor in the Department of Pharmacology and Toxicology, at the Boonshoft School of Medicine, Wright State University, Dayton, Ohio. He has been a Diplomat of the American Board of Toxicology (DABT) since 1991 and been actively involved in the Society of Toxicology since 1981, a full member since 1990, having served as president and counselor for the Biological Modeling Specialty Section, and counselor for the Inhalation and Respiratory Specialty Section. Dr. Gearhart received his B.S. in Biology from the University of New Mexico and his M.S. while working at the Lovelace Inhalation Toxicology Research Institute, under Dr. Roger O. McClellan. He then studied inhalation and systemic toxicology at the Institute of Environmental Medicine at New York University, with Drs. Richard B. Schesinger and Dr. Morton Lippmann, receiving his Ph.D. in Environmental Health and Toxicology in 1987. Dr. Gearhart practiced corporate toxicology at The Proctor and Gamble Co after working with Drs. Kenneth Crump at the KS Crump Group and Dr. Harvey Clewell III consulting to a wide range of corporate clients in both the private and government sector. Dr. Zhoumeng Lin is an Associate Professor in the Department of Environmental and Global Health at College of Public Health and Health Professions at the University of Florida. He is a member of the Center for Environmental and Human Toxicology (CEHT) and the Center for Pharmacometrics and Systems Pharmacology (CPSP). He received a B.Med. in Preventive Medicine from Southern Medical University in China in 2009 and a Ph.D. in Toxicology from the University of Georgia in 2013. He completed his postdoctoral training in Computational Toxicology in the Institute of Computational Comparative Medicine at Kansas State University in 2016. He was an Assistant Professor from 2016 to 2021 and then an Associate Professor from March to May 2021 at Kansas State University, prior to joining the University of Florida as an Associate Professor in May 2021. Dr. Lin’s research is focused on the development and application of computational technologies, especially physiologically based pharmacokinetic (PBPK) modeling, machine learning, and artificial intelligence approaches, to study nanomedicine, food safety, nanoparticle and chemical risk assessment. He is a co-author of more than 100 peer-reviewed manuscripts. He teaches two graduate level courses entitled “Physiologically Based Pharmacokinetic Modeling in Toxicology and Risk Assessment and “Artificial Intelligence in Toxicology and Environmental Health.
Foreword
Melvin Andersen
Preface
Jeffrey W. Fisher, Zhoumeng Lin and Jeffery M. Gearhart
1. A history and recent efforts of selected physiologically based pharmacokinetic modeling topics
Zhoumeng Lin and Jeffrey W. Fisher
2. Introduction to classical pharmacokinetics
Shruti V. Kabadi and Zhoumeng Lin
3. Fundamentals of physiologically based pharmacokinetic modeling
Jeff Fisher, Xiaoxia Yang, Darshan Mehta, Conrad Housand and Zhoumeng Lin
4. Physiologically based pharmacokinetic modeling software
C.E. Hack, A.Y. Efremenko, S.N. Pendse, C.A. Ellison, A. Najjar, N. Hewitt, A. Schepky and H.J. Clewell III
5. Chemical absorption and writing code for portals of entry
Jeffrey W. Fisher, Jeffery M. Gearhart, Jerry L. Campbell Jr and Darshan Mehta
6. Physiologically based pharmacokinetic model: distribution processes
Christopher Ruark
7. Metabolism and physiologically based pharmacokinetic models
Jeffrey W. Fisher, Jerry L. Campbell Jr. and Zhoumeng Lin
8. Physiologically based pharmacokinetic model: excretion via urine, feces, and breath
Sami Haddad and Andy Nong
9. Sensitivity and Monte Carlo analysis techniques and their use in uncertainty, variability, and population analysis
Tammie R. Covington and Jeffery M. Gearhart
10. Physiologically based pharmacokinetic model calibration, evaluation, and performance assessment
Zhoumeng Lin, Yi-Hsien Cheng, Wei-Chun Chou and Miao Li
11. Examples of physiologically based pharmacokinetic modeling applied to risk assessment
Lisa M. Sweeney and Jeffery M. Gearhart
12. Physiologically based pharmacokinetic models to support modernized chemical safety assessment
Miyoung Yoon
| Erscheinungsdatum | 01.06.2020 |
|---|---|
| Verlagsort | San Diego |
| Sprache | englisch |
| Maße | 191 x 235 mm |
| Gewicht | 840 g |
| Themenwelt | Mathematik / Informatik ► Mathematik ► Angewandte Mathematik |
| Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie | |
| Studium ► Querschnittsbereiche ► Prävention / Gesundheitsförderung | |
| ISBN-10 | 0-12-818596-1 / 0128185961 |
| ISBN-13 | 978-0-12-818596-4 / 9780128185964 |
| Zustand | Neuware |
| Informationen gemäß Produktsicherheitsverordnung (GPSR) | |
| Haben Sie eine Frage zum Produkt? |
aus dem Bereich
