Computational Stem Cell Biology

Methods and Protocols

Buch | Hardcover

456 Seiten

2019 | 2019 ed.
Humana Press Inc. (Verlag)
978-1-4939-9223-2 (ISBN)

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This volume details methods and protocols to further the study of stem cells within the computational stem cell biology (CSCB) field. Chapters are divided into four sections covering the theory and practice of modeling of stem cell behavior, analyzing single cell genome-scale measurements, reconstructing gene regulatory networks, and metabolomics. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Authoritative and cutting-edge, Computational Stem Cell Biology: Methods and Protocols will be an invaluable guide to researchers as they explore stem cells from the perspective of computational biology.

Agent-Based Modeling to Delineate Spatiotemporal Control Mechanisms of the Stem Cell Niche.- Modeling Cellular Differentiation and Reprogramming with Gene Regulatory Networks.- Cell Population Model to Track Stochastic Cellular Decision-Making during Differentiation.- Automated Formal Reasoning to Uncover Molecular Programs of Self-Renewal.- Mathematical Modeling of Clonal Stem Cell Dynamics.- Computational Tools for Quantifying Concordance in Single Cell Fate.- Quantitative Modeling of the Waddington Epigenetic Landscape.- Modeling Gene Networks to Understand Multistability in Stem Cells.- Trajectory Algorithms to Infer Stem Cell Fate Decisions.- Gene Regulatory Networks from Single Cell Data for Exploring Cell Fate Decisions.- Reconstructing Gene Regulatory Networks that Control Hematopoietic Commitment.- Investigating Cell Fate Decisions with ICGS Analysis of Single Cells.- Lineage Inference and Stem Cell Identity Prediction using Single Cell RNA-Sequencing Data.- Dynamic Network Modeling of Stem Cell Metabolism.- Metabolomics in Stem Cell Biology Research.- Molecular Interaction Networks to Select Factors for Cell Conversion.- A Computational Approach for Cell Fate Reprogramming.- Computational Analysis of Aneuploidy in Pluripotent Stem Cells.- Cell Fate Engineering Tools for iPSC Disease Modeling.

Erscheinungsdatum	22.05.2019
Reihe/Serie	Methods in Molecular Biology ; 1975
Zusatzinfo	95 Illustrations, color; 12 Illustrations, black and white; XI, 456 p. 107 illus., 95 illus. in color.
Verlagsort	Totowa, NJ
Sprache	englisch
Maße	178 x 254 mm
Themenwelt	Mathematik / Informatik ► Informatik ► Theorie / Studium
	Informatik ► Weitere Themen ► Bioinformatik
	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
	Naturwissenschaften ► Biologie ► Zellbiologie
Schlagworte	engineered cells • fetal tissues • gene regulatory networks • single-cell transcriptome data • teratomas
ISBN-10	1-4939-9223-6 / 1493992236
ISBN-13	978-1-4939-9223-2 / 9781493992232
Zustand	Neuware