Computational Methods for Processing and Analysis of Biological Pathways

Anastasios Bezerianos, Andrei Dragomir, Panos Balomenos (Autoren)

Buch | Softcover

VIII, 87 Seiten

2017 | 1st ed. 2017
Springer International Publishing (Verlag)
978-3-319-53867-9 (ISBN)

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This work offers a guided walkthrough of one of the most promising research areas in modern life sciences, enabling a deeper understanding of involved concepts and methodologies via an interdisciplinary view, focusing on both well-established approaches and cutting-edge research. Highlighting what pathway analysis can offer to both the experimentalist and the modeler, the text opens with an introduction to a general methodology that outlines common workflows shared by several methods. This is followed by a review of pathway and sub-pathway based approaches for systems pharmacology. The work then presents an overview of pathway analysis methods developed to model the temporal aspects of drug- or disease-induced perturbations and extract relevant dynamic themes. The text concludes by discussing several state-of-the-art methods in pathway analysis, which address the important problem of identifying differentially expressed pathways and sub-pathways.

Anastasios Bezerianos is a Professor at the Medical School of Patras University, Greece. He is also a Senior Principal Research Fellow at the Singapore Institute for Neurotechnology (SINAPSE) within the Centre for Life Sciences (CeLS), a Research Professor in the Department of Electrical and Computer Engineering (ECE), and a member of the Faculty of NUS Graduate School (NGS) for Integrative Sciences and Engineering at the National University of Singapore (NUS). Andrei Dragomir is a Research Assistant Professor at the Department of Biomedical Engineering of the University of Houston, TX, USA. Panos Balomenos is a PhD Candidate at the Computer Engineering and Informatics Department of the University of Patras, Greece.

Introduction.- Networks and Pathways in Systems Pharmacology.- Time Varying Methods for Pathway and Sub-Pathway Analysis.- Identification of Differentially Expressed Pathways and Sub-Pathways.

Erscheinungsdatum	10.04.2017
Reihe/Serie	SpringerBriefs in Computer Science
Zusatzinfo	VIII, 87 p. 11 illus. in color.
Verlagsort	Cham
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Informatik ► Weitere Themen ► Bioinformatik
Themenwelt	Naturwissenschaften ► Biologie
Schlagworte	Bioinformatics • Computational Biology/Bioinformatics • Computer Science • graph theory • Information technology: general issues • Life sciences: general issues • network biology • pathway analysis • systems biology
ISBN-10	3-319-53867-5 / 3319538675
ISBN-13	978-3-319-53867-9 / 9783319538679
Zustand	Neuware