Concepts in Bioinformatics and Genomics
Oxford University Press Inc (Verlag)
978-0-19-993699-1 (ISBN)
program-coding methodology underpinning this exciting field.
Jamil Momand is Professor of Biochemistry at California State University, Los Angeles. He received the Cal State LA Outstanding Professor Award for the 2014-2015 academic year. Alison McCurdy is Professor of Chemistry at California State University, Los Angeles. She was the recipient of the 2009 California State University Distinguished Woman Award.
Preface
About the Author
Chapter I: Review of Molecular Biology
Learning outcomes
1.1 Genes and DNA
1.2 RNA-the intermediary
1.3 Amino acids-the building blocks of proteins
1.4 Levels of protein structure
1.5 The genetic code
1.6 Relative sizes of matter
1.7 DNA alterations
1.8 A case study: sickle cell anemia
· What are the symptoms of sickle cell anemia?
· Sickle cell anemia is the first disease linked to a specific mutation
1.9 Introduction to p53
Summary
`L Exercises
References
Box 1-1. A Closer Look: A rare inherited cancer is caused by mutated Tp53
Chapter 2: Information organization and sequence databases
Learning outcomes
2.1 Introduction
2.2 Public databases
2.3 The header
2.4 The feature keys
· The CDS feature key and gene structure
· The gene feature key and FASTA format
· Thought Question 2.1
2.5 Limitations of GenBank
2.6 Reference Sequence (RefSeq)
· Alternative splicing
2.7 Primary and secondary databases
· The UniProt Knowledge Base (UniProtKB) database
Summary
Exercises
Answers to Thought Questions
References
Box 2-1. Scientist Spotlight: Walter Goad, GenBank Founder
Box 2-2. A Closer Look: GenBank is Critical to the Discovery of the MDM2 Oncoprotein-an Inhibitor of p53
Chapter 3: Molecular Evolution
Learning outcomes
3.1 Introduction
3.2 Conserved regions in proteins
3.3 Molecular Evolution
· Transformation of normal cells to cancer cells
· Are mutations inherited?
· Natural selection
· Mechanisms of mutation
3.4 Ancestral genes and protein evolution
3.5 Modular proteins and protein evolution
Summary
Exercises
References
Box 3-1. Scientist Spotlight: Barbara McClintock
Chapter 4: Substitution matrices
Learning outcomes
4.1 Introduction
4.2 The identity substitution matrix
4.3 An amino acid substitution system based on natural selection
4.4 Development of the matrix of
| Erscheinungsdatum | 07.08.2016 |
|---|---|
| Zusatzinfo | Illustrations |
| Verlagsort | New York |
| Sprache | englisch |
| Themenwelt | Mathematik / Informatik ► Informatik ► Software Entwicklung |
| Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie | |
| ISBN-10 | 0-19-993699-4 / 0199936994 |
| ISBN-13 | 978-0-19-993699-1 / 9780199936991 |
| Zustand | Neuware |
| Informationen gemäß Produktsicherheitsverordnung (GPSR) | |
| Haben Sie eine Frage zum Produkt? |
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