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Rule-Based Modeling in Systems Biology

James Faeder, William S. Hlavacek (Autoren)

Buch | Hardcover

350 Seiten

2017
Apple Academic Press Inc. (Verlag)
978-1-4822-3631-6 (ISBN)

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This book covers computational modeling of "biomolecular site dynamics". It also describes the use of rule-based modeling, in coordination with quantitative experimental approaches, to gain insights into site dynamics and to introduce the basic concepts and techniques of rule-based modeling. The book is divided into three parts. The first part covers the biological significance and physical chemistry of site dynamics. The second part provides an introduction to the essential methodology of rule-based modeling. The third part consists of examples of rule-based modeling capabilities.

INTRODUCTION. The biological and physicochemical foundations of biomolecular site dynamics. Motivation and background. Qualitative aspects of biomolecular interaction networks. Quantitative aspects of protein site dynamics. Quantitative aspects of protein site dynamics. Essential methodology. Overview of methods for specifying, visualizing and annotating models. Simulation techniques for non-spatial modeling. A survey of simulation techniques for spatial modeling. Methods for analyzing models. Example uses of rule-based modeling techniques. Multisite phosphorylation. Aggregation and self assembly. Allosteric regulation. Gene regulation. Isotopomer dynamics.

Erscheint lt. Verlag	6.7.2017
Reihe/Serie	Chapman & Hall/CRC Mathematical and Computational Biology
Verlagsort	Oakville
Sprache	englisch
Maße	156 x 234 mm
Themenwelt	Mathematik / Informatik ► Mathematik ► Angewandte Mathematik
	Medizin / Pharmazie
	Naturwissenschaften ► Biologie
	Naturwissenschaften ► Physik / Astronomie ► Angewandte Physik
ISBN-10	1-4822-3631-1 / 1482236311
ISBN-13	978-1-4822-3631-6 / 9781482236316
Zustand	Neuware