Role of Products of the Histocompatibility Gene Complex in Immune Responses (eBook)

Baruj Benacerraf, David H. Katz (Herausgeber)

eBook Download: EPUB

2014 | 1. Auflage
802 Seiten
Elsevier Science (Verlag)
978-1-4832-7344-0 (ISBN)

Infos

The Role of Products of the Histocompatibility Gene Complex in Immune Responses documents the proceedings of a conference held on 3-7 November 1975, which brought together an international group of scientists spanning three independent disciplines-genetics and immunogenetics, molecular biochemistry, and immunobiology-with clinical medicine overlapping these disciplines. This volume contains 42 papers organized according to the eight sessions held at the conference. The papers in Session I examined the genetics of the major histocompatibility complex. Session II presented studies on the biology of mixed lymphocyte interactions and cell-mediated cytotoxicity reactions. Session III discussed immune response gene systems while Session IV dealt with the genetic control of cell interactions. The papers in Session V covered idiotypic determinants on T cell receptors. Session VI investigated the properties of histocompatibility gene products involved in regulation of immune responses. Session VII focused on the biochemistry and immunocytology of cell surface products of the major histocompatibility complex. Finally, Session VIII discussed interrelationships between products of the major histocompatibility complex and their relevance to disease.

Inhalt

Front Cover 1
The Role of Products of the Histocompatibility Gene Complex in 
4 
Copyright Page 5
Table of Contents 6
Participants 12
Preface 16
PHOTOGRAPHS OF PARTICIPANTS 20
SESSION I: Genetics of the Major Histocompatibility Complex 24
CHAPTER 1. GENETIC RESOLUTION OF THE PRODUCTS AND FUNCTIONS OF I AND S REGION GENES OF THE MOUSE H-2 
26 
Abstract 26
INTRODUCTION 27
GENETIC ORGANIZATION OF THE H-2 
27 
THE ROLE OF THE S 
28 
THE SEROLOGICALLY DETECTED 1 REGION PRODUCTS: 
33 
POSSIBLE PATTERNS OF GENETIC ORGANIZATION OF THE 1 REGION 41
ACKNOWLEDGMENTS 45
REFERENCES 46
DISCUSSION FOLLOWING DONALD SHREFFLER 51
CHAPTER 2. THE GENETICS OF THE MAJOR HISTOCOMPATIBILITY COMPLEX IN 
54 
INTRODUCTION 55
THE HLA SUPERGENE AND THE 6TH CHROMOSOME 55
THE GENETICS OF THE D(MLC-s) LOCUS 58
HLA AND DISEASE ASSOCIATIONS 66
HLA AND IMMUNE RESPONSE 67
REFERENCES 69
DISCUSSION FOLLOWING JON van ROOD 73
CHAPTER 3. MOLECULAR RELATIONSHIPS OF la ANTIGENS CONTROLLED BY THE SAME 
76 
ACKNOWLEDGEMENTS 80
REFERENCES 81
CHAPTER 4. Br AND Wh, B CELL ANTIGENS IN GLUTEN SENSITIVE ENTEROPATHY 
82 
INTRODUCTION 82
MATERIALS AND METHODS 84
DISCUSSION 88
ACKNOWLEDGMENT 90
REFERENCES 91
CHAPTER 5. RECENT STUDIES OF la LIKE ANTIGENS AND COMPLEMENT COMPONENTS 
94 
THE ROCKEFELLER UNIVERSITY AND 
94 
COMPLEMENT-MHC RELATIONSHIPS 96
REFERENCES 98
CHAPTER 6. 
100 
INTRODUCTION 100
SPECIFICITY OF 
101 
AGE VARIATION OF NATURAL KILLER 
102 
EFFECTOR CELL ANALYSIS OF NATURAL KILLER 
102 
GENETIC ANALYSIS OF NATURAL KILLER CELL ACTIVITY 104
IN VIVO RELEVANCE OF 
104 
CONCLUSIONS 106
ACKNOWLEDGEMENTS 107
REFERENCES 107
CHAPTER 7. EVIDENCE FOR THE ASSOCIATION OF SPECIFICITY la.3 
110 
REFERENCES 111
GENERAL DISCUSSION - SESSION I: 
114 
SESSION II: The Biology of Mixed Lymphocyte Interactions and Cell-mediated Cytotoxicity Reactions 124
CHAPTER 8. GENETIC AND CELLULAR ASPECTS OF MIXED LEUKOCYTE CULTURE AND 
126 
GENETIC CONTROL OF MLC — THE MHC LD SYSTEM 128
GENETIC CONTROL OF CML — "LD-SD COLLABORATION 129
CELLULAR RECOGNITION OF MHC ANTIGENS 131
SECONDARY RESPONSES IN VITRO 133
PRIMED LD TYPING (PLT) TEST 133
RESTIMULATION OF CYTOXICITY 136
MODEL — AN ATTEMPT AT SYNTHESIS 139
IN VIVO LD-SD COLLABORATION 144
SUMMARY 146
REFERENCES 147
ACKNOWLEDGEMENT 151
DISCUSSION FOLLOWING FRITZ BACH 152
CHAPTER 9. BIFUNCTIONAL HISTOCOMPATIBILITY-LINKED REGULATION OF CELL MEDIATED LYMPHOLYSIS TO MODIFIED AUTOLOGOUS CELL 
156 
INTRODUCTION 157
REQUIREMENT FOR H-2 HOMOLOGY OF MODIFIED TARGET CELLS WITH 
158 
SPECIFICITY OF CYTOTOXICITY AS A FUNCTION OF THE MODIFYING AGENT 164
EFFECTOR CELL SPECIFICITY: MODIFIED AUTOLOGOUS H-2 
164 
CONCLUSIONS AND SPECULATIONS 173
ACKNOWLEDGMENTS 175
REFERENCES 175
DISCUSSION FOLLOWING GENE SHEARER 178
CHAPTER 10. 
182 
INTRODUCTION 182
MATERIALS AND METHODS 183
RESULTS 183
DISCUSSION 186
REFERENCES 187
CHAPTER 11. H-2 ASSOCIATED MLR DETERMINANTS: IMMUNOGENETICS OF THE LOC 
190 
MAPPING OF MLR GENES 190
MLR ASSAY IN RECOMBINANT SCREENING 191
THE INHIBITION OF MLR WITH ANTI-la SERA 193
ACKNOWLEDGMENTS 200
REFERENCES 200
CHAPTER 12. RESPONSES OF ALLOANTIGEN REACTIVE LYMPHOCYTES TO CONVENTIONAL 
202 
REFERENCES 205
CHAPTER 13. EVIDENCE FOR SEVERAL CLOSELY LINKED GENES INVOLVED 
206 
INTRODUCTION 207
EVIDENCE THAT TWO D-LOCUS HOMOZYGOUS TYPING 
207 
EVIDENCE FOR DIFFERENCES IN D-LOCUS SPECIFICITY 
208 
CONCLUSIONS 214
ACKNOWLEDGEMENTS 215
REFERENCES 215
CHAPTER 14. 
216 
INTRODUCTION 216
EXPERIMENTAL DETAILS 217
RESULTS 218
DISCUSSION 221
ACKNOWLEDGMENTS 224
REFERENCES 224
CHAPTER 15. DOES THE APPARENT H-2 COMPATIBILITY REQUIREMENT FOR VIRUS–SPECIFIC T CELL-MEDIATED CYTOLYSIS REFLECT T CELL SPECIFICITY FOR "ALTERED SELF" OR PHYSIOLOGICAL 
226 
ACKNOWLEDGMENTS 232
REFERENCES 233
GENERAL DISCUSSION - SESSION II: 
236 
SESSION III: 
246 
CHAPTER 16. THE NATURE AND FUNCTION OF SPECIFIC H-LINKED 
248 
THE ACTIVITIES OF COMPLEMENTING HISTOCOMPATIBILITY-LINKED 
248 
CIS-TRANS EFFECTS IN THE COMPLEMENTING OF a AND ß 
260 
GENETIC CONTROL OF SPECIFIC IMMUNE SUPPRESSION 262
STRAIN DIFFERENCES IN THE SUPPRESSION BY GT 
266 
REFERENCES 268
DISCUSSION FOLLOWING BARUJ BENACERRAF 272
CHAPTER 17. FUNCTIONAL ANALYSIS OF la ANTIGENS 
280 
INTRODUCTION 280
la ANTIGEN EXPRESSION ON B CELL 
282 
la ANTIGEN EXPRESSION ON T CELL SUBPOPULATIONS 286
DISCUSSION 293
ACKNOWLEDGMENTS 296
REFERENCES 297
DISCUSSION FOLLOWING HUGH McDEVITT 299
CHAPTER 18. 
306 
ACKNOWLEDGEMENTS 309
REFERENCES 309
CHAPTER 19. H-3-LINKED UNRESPONSIVENESS TO EA-1 AND H-13 
312 
INTRODUCTION 312
EVIDENCE FOR THE MAP POSITION OF IR-2 313
UNRESPONSIVENESS OF YBR MICE MADE TOLERANT 
314 
H-3-LINKED LOW RESPONSE TO H-13 ANTIGENS 315
CONCLUSION 315
ACKNOWLEDGEMENTS 318
REFERENCES 318
CHAPTER 20. IMMUNE RESPONSES OF MICE AGAINST MODIFIED RANDOM POLYMERS 
320 
INTRODUCTION 320
RESPONSE TO GL COPOLYMERS MODIFIED WITH VARIOUS AMINO ACIDS 321
DISCUSSION 324
ACKNOWLEDGMENTS 327
REFERENCES 328
CHAPTER 21. A POSSIBLE FUNCTION FOR PRODUCTS OF THE MAJOR HISTOCOMPATIBILITY 
330 
INTRODUCTION 330
MATERIALS AND METHODS 331
RESULTS 331
DISCUSSION 333
REFERENCES 335
GENERAL DISCUSSION - SESSION III: 
336 
COMMENTARY 344
SESSION IV: 
356 
CHAPTER 22. MACROPHAGE-T LYMPHOCYTE INTERACTION: THE CELLULAR BASIS 
358 
I. MACROPHAGE FUNCTION IN ANTIGEN SPECIFIC T CELL ACTIVATION 358
II. HOW DO 
360 
III. IMMUNE RESPONSE GENE FUNCTION IN MACROPHAGE-T 
362 
IV. GENETIC ANALYSIS OF DETERMINANTS MEDIATING MACROPHAGE 
365 
V. ROLE OF MACROPHAGE-ASSOCIATED ANTIGEN IN THE 
368 
REFERENCES 372
DISCUSSION FOLLOWING ALAN ROSENTHAL 374
CHAPTER 23. GENETIC CONTROL OF LYMPHOCYTE INTERACTIONS AND 
378 
EVIDENCE FOR GENETIC RESTRICTIONS IN COOPERATIVE T-B CELL 
379 
EVIDENCE FOR FUNCTIONAL INTERRELATIONSHIPS BETWEEN CI AND Ir 
387 
THE CONCEPTS OF "ADAPTIVE DIFFERENTIATION" 
396 
CONCLUSION 404
ACKNOWLEDGMENTS 405
REFERENCES 406
DISCUSSION FOLLOWING DAVID KATZ 409
CHAPTER 24. STIMULATION OF ANTIBODY RESPONSES IN VITRO BY 
414 
INTRODUCTION 414
EXPERIMENTAL SYSTEM 416
ABILITY OF SYNGENEIC AND ALLOGENEIC MACROPHAGES TO 
416 
ABILITY OF SYNGENEIC AND ALLOGENEIC MACROPHAGES TO SUPPORT DEVELOPMENT OF SECONDARY ANTIBODY 
418 
DISCUSSION 421
ACKNOWLEDGEMENTS 423
REFERENCES 423
CHAPTER 25. H-2 LINKED Ir GENE REGULATION OF DELAYED-TYPE 
426 
INTRODUCTION 426
METHODS 426
RESULTS AND DISCUSSION 427
SUMMARY 436
REFERENCES 437
CHAPTER 26. DIFFERENTIAL EXPRESSION OF la ANTIGENS ON SUPPRESSOR T 
440 
la ANTIGENS ON FUNCTIONAL LYMPHOCYTE 
442 
ARE la ANTIGENS SECRETED BY 
445 
ACKNOWLEDGEMENTS 446
REFERENCES 446
CHAPTER 27. EFFECTIVE ALLOGENEIC T CELL-B CELL INTERACTION 
448 
INTRODUCTION 448
RESULTS 448
ACKNOWLEDGMENTS 454
REFERENCES 455
GENERAL DISCUSSION - SESSION IV: 
456 
SESSION V: Idiotypic Determinants on T Cell 
466 
CHAPTER 28. T LYMPHOCYTE RECEPTOR ANALYSIS 
468 
INTRODUCTION 468
SENSITIZATION BY ANTI-IDIOTYPIC ANTIBODY 470
HELPER CELLS INDUCED BY ANTI-IDIOTYPIC ANTI 
472 
ACKNOWLEDGEMENTS 477
REFERENCES 477
DISCUSSION FOLLOWING KLAUS RAJEWSKY 479
CHAPTER 29. 
484 
INTRODUCTION 485
DEMONSTRATION OF ANTI-IDIOTYPIC ANTIBODIES REACTIVE WITH 
486 
VISUALIZATION: FREQUENCY-DETERMINATION AND PHYSICAL 
488 
A SPECULATIVE DISCUSSION OF THE FREQUENCY OF 
490 
PRESENCE OF IDIOTYPIC MOLECULES WITH ANTI-AG-B ACTIVITY 
491 
DEMONSTRATION OF CELLULAE ORIGIN OF NATURALLY PRODUCED, 
493 
SPECULATIONS AS TO THE STRUCTURE OF 
495 
REFERENCES 497
ACKNOWLEDGEMENTS 498
DISCUSSION FOLLOWING HANS WIGZELL 499
SESSION VI: Properties of Histocompatibility Gene Products Involved in Regulation of Immune Responses 506
CHAPTER 30. THE NATURE OF ANTIGEN SPECIFIC T CELL FACTORS INVOLVED IN 
508 
INTRODUCTION 509
SPECIFICITY OF T CELL FACTORS 510
ISOLATION AND PURIFICATION OF A T CELL FACTOR PRODUCED WITH 
513 
THE T CELL FACTOR SPECIFIC FOR (T,G)-Pro—L IS A PRODUCT OF 
518 
EFFECT OF T CELL FACTORS ON THE SPLENIC LEVELS OF CYCLIC AMP IN MICE 524
CONCLUDING REMARKS 525
ACKNOWLEDGMENTS 526
REFERENCES 527
DISCUSSION FOLLOWING EDNA MOZES 529
CHAPTER 31. CHARACTERIZATION OF THE ANTIGEN-SPECIFIC SUPPRESSIVE T CELL FACTOR WITH SPECIAL REFERENCE TO 
536 
INTRODUCTION 537
GENERAL FEATURES OF THE ANTIGEN-SPECIFIC 
538 
THE ANTIGEN-SPECIFIC SUPPRESSIVE T CELL FACTOR AS AN I 
541 
REQUIREMENT FOR HISTOCOMPATIBILITY IN THE EFFECTIVE 
547 
DISCUSSION 552
ACKNOWLEDGEMENTS 555
REFERENCES 556
DISCUSSION FOLLOWING TOMIO TADA 558
CHAPTER 32. 
564 
INTRODUCTION 564
GENETIC AND CELLULAR REQUIREMENTS FOR AEF PRODUCTION 565
BIOLOGICAL PROPERTIES OF AEF 566
PHYSICOCHEMICAL AND BIOCHEMICAL PROPERTIES OF AEF 566
IMMUNOLOGICAL AND IMMUNOCHEMICAL PROPERTIES OF AEF 567
RELATIONSHIP OF AEF TO OTHER BIOLOGICALLY ACTIVE FACTORS 
572 
CONCLUSIONS 573
ACKNOWLEDGMENTS 573
REFERENCES 574
CHAPTER 33. 
576 
REFERENCES 588
CHAPTER 34. SUPPRESSIVE ACTIVITY OF LYMPHOID CELL EXTRACTS FROM NON-RESPONDER MICE INJECTED WITH THE TERPOLYMER L-GLUTAMIC ACID60- L-ALANINE30- L-TYROSINE10 
592 
INTRODUCTION 592
COMPARISON OF LYMPHOID CELL EXTRACTS FROM 
593 
ANTIGENIC SPECIFICITY OF THE EXTRACT 596
ESTIMATE OF MOLECULAR WEIGHT 596
ACKNOWLEDGEMENTS 597
REFERENCES 598
CHAPTER 35. ANTI -ß2MICROGLOBULIN - A SELECTIVE PBA FOR HUMAN AND MOUSE B 
602 
INTRODUCTION 602
THE ACTIVE MITOGENIC PRINCIPLE IN ANTISERA AGAINST 
603 
OPTIMAL CONDITIONS FOR MITOGENICITY OF ANTIBODIES TO 
604 
B CELLS ARE DIRECTLY ACTIVATED BY ANTI- 
606 
DOES ANTI-ß2MICROGLOBULIN ACTIVATE A SPECIFIC SUBSET 
607 
WHICH CELL RECEPTOR IS RESPONSIBLE FOR THE MITOGENIC 
611 
ACKNOWLEDGEMENTS 613
REFERENCES 614
GENERAL DISCUSSION - SESSION VI: PROPERTIES OF HISTOCOMPATIBILITY GENE PRODUCTS INVOLVED IN 
616 
SESSION VII: Biochemistry and Immunocytology of Cell Surface Products of the Major Histocompatibility Complex 624
CHAPTER 36. 
626 
INTRODUCTION 626
MAPPING STUDIES 627
REDISTRIBUTION 631
CO-CAPPING 633
ACKNOWLEDGEMENTS 637
REFERENCES 637
DISCUSSION FOLLOWING EMIL UNANUE 640
CHAPTER 37. ISOLATION AND STRUCTURE OF PRODUCTS OF THE HUMAN 
644 
INTRODUCTION 644
HL-A ANTIGENS FROM HUMAN LYMPHOCYTES 644
B CELL SPECIFIC ANTIGENS FROM HUMAN LYMPHOCYTES 656
ACKNOWLEDGMENTS 660
REFERENCES 665
DISCUSSION FOLLOWING JACK STROMINGER 667
CHAPTER 38. STUDIES ON THE CHEMICAL BASIS OF VARIABILITY AND THE COMPLEX CELLULAR EXPRESSION OF THE H-2K and H-2D PRODUCTS 670
INTRODUCTION 671
STUDIES ON THE PEPTIDE ANALYSIS OF SELECTED H-2K AND H-2D GENE PRODUCTS 672
STUDIES ON THE POLYMORPHISM AND INTRAMOLECULAR ARRANGEMENT OF THE H-2 GLYCOPROTEINS 677
STUDIES ON SOMATIC CELL VARIANTS IN H-2 
681 
CONCLUDING THOUGHTS 684
ACKNOWLEDGMENTS 685
REFERENCES 686
DISCUSSION FOLLOWING STANLEY NATHENSON 688
CHAPTER 39. 
690 
INTRODUCTION 690
STRUCTURE OF H-2 ANTIGENS 691
COMPARISON OF PARTIAL AMINO ACID SEQUENCES 694
FUNCTIONAL STUDIES 696
REFERENCES 698
CHAPTER 40. GENETIC AND 
700 
INTRODUCTION 700
MATERIALS AND METHODS 702
RESULTS 702
DISCUSSION 705
ACKNOWLEDGMENTS 709
REFERENCES 710
CHAPTER 41. 
714 
INTRODUCTION 714
METHODS 715
CHEMISTRY AND STRUCTURE 716
IMMUNOGENETIC STUDIES 718
TISSUE DISTRIBUTION 721
QUESTIONS TO BE ANSWERED 723
REFERENCES 723
GENERAL DISCUSSION - SESSION VII: BIOCHEMISTRY AND IMMUNOCYTOLOGY OF CELL SURFACE PRODUCTS 
726 
SESSION VIII: Interrelationships Between Products of the Major Histocompatibility Complex and Their Relevance to Disease 736
CHAPTER 42. GENERAL DISCUSSION - SESSION VIII: INTERRELATIONSHIPS BETWEEN PRODUCTS OF THE MAJOR 
738 
1. a) SPECIFICITY OF H-LINKED 
745 
1. b) MICROHETEROGENEITY OF la MOLECULES 751
2. EVIDENCE FOR EXISTENCE OF A DISTINCT I-B SUB-REGION 754
3. a,b,c) NATURE OF THE ANTIGEN RECEPTOR ON T CELL FACTORS AND RELATIONSHIP TO VH REGIONS AND Ig IDIOTYPES THEIR SPECIFICITY RANGE AS COMPARED TO IMMUNOGLOBULINS
4. SIMILARITIES AND DIFFERENCES BETWEEN HELPER AND SUPPRESSOR FACTORS 771
5. BASIS FOR THE LARGE NUMBERS OF ALLOSPECIFIC T CELLS RECOGNIZING MHC ANTIGENS 775
6. THE PHENOMENON OF CIS-TRANS PREFERENCE IN COMPLEMENTATION OF IT GENES AND ITS RELEVANCE TO 
786 
7. THE BASIS FOR PRESENCE OR ABSENCE OF GENETIC RESTRICTIONS IN 
788 
RELATIONSHIP OF THE MHC TO HUMAN DISEASE 797

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Participants

D. Bernard Amos,     Department of Microbiology and Immunology, Duke University Medical Center, Durham, North Carolina 27710

Dieter Armerding,     Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115

Fritz H. Bach,     Immunobiology Research Center, University of Wisconsin, Madison, Wisconsin 53706

Baruj Benacerraf,     Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115

Kathleen Bechtol,     Department of Zoology, University of Oxford, South Parks Road, Oxford OX 1 3PS England

Bruce A. Cunningham,     Rockefeller University, New York, New York 10021

Jean Dausset,     Université de Paris VII, Hospital St. Louis, Place du Docteur-Fournier, Paris, France

Martin E. Dorf,     Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115

Bo Dupont,     Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021

David L. Gasser,     Department of Human Genetics, University of Pennsylvania, Philadelphia, Pennsylvania 19174

Richard Gershon,     Department of Pathology, Yale Medical School, New Haven, Connecticut 06510

Ira Green,     Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014

Howard Grey,     National Jewish Hospital and Research Center, Denver, Colorado 80206

Günter Hämmerling,     Institut für Genetik, der Universität zu Köln, 5 Köln-Lindenthal, Weyertal 121 Germany

Leroy Hood,     Department of Biology, California Institute of Technology, Pasadena, California 91109

Bernard W. Janicki,     Extramural Programs, National Institute of Allergy & Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014

Judith Kapp,     Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115

David H. Katz,     Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115

Rolf Kiessling,     Department of Tumor Biology, Karolinska Institutet, S-104 01 Stockholm 60, Sweden

George Klein,     Department of Tumor Biology, Karolinska Institutet, S-104 01 Stockholm 60, Sweden

Jan Klein,     Department of Microbiology, University of Texas, Southwestern Medical School, Dallas, Texas 75235

Henry G. Kunkel,     Rockefeller University, New York, New York 10021

Rose Lieberman,     Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014

Paul H. Maurer,     Department of Biochemistry, Jefferson Medical College, Philadelphia, Pennsylvania 19107

Hugh O. McDevitt,     Department of Medicine, Stanford University Medical Center, Stanford, California 94305

Tommaso Meo,     Department of Genetics, Washington University School of Medicine, St. Louis, Missouri 63110

J.F.A.P. Miller,     The Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria 3050, Australia

Erna Möller,     Division of Immunobiology, Karolinska Institute, Wallenberg Laboratory, 104 05 Stockholm 50, Sweden

Edna Mozes,     Department of Chemical Immunology, Weizmann Institute of Science, Rehovoth, Israel

Alan J. Munro,     Immunology Division, Department of Pathology, Tennis Court Road, Cambridge, England

Stanley G. Nathenson,     Dept. Microbiology and Immunobiology, Albert Einstein College of Medicine, Bronx, New York 10461

G.J.V. Nossal,     The Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria 3050, Australia

William E. Paul,     Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014

Carl W. Pierce,     Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115

Klaus Rajewsky,     Institut für Genetik der, Universität zu Köln, 5 Köln-Lindenthal, Weyertal 121, Germany

Alan Rosenthal,     Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014

David H. Sachs,     Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014

Michael Sela,     Department of Chemical Immunology, Weizmann Institute of Science, Rehovoth, Israel

Gene M. Shearer,     Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014

Ethan M. Shevach,     Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014

Donald C. Shreffler,     Department of Genetics, Washington University School of Medicine, St. Louis, Missouri 63110

Morten Simonsen,     University of Copenhagen, Nørre Alle 71, DK 2100 Copenhagen Ø, Denmark

Jack H. Stimpfling,     McLaughlin Research Institute, Columbus Hospital, Great Falls, Montana 59401

Jack L. Strominger,     Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, Massachusetts 02138

Tomio Tada,     Immunology Research Laboratories, School of Medicine, Chiba University, Chiba, Japan

Michael Taussig,     Basel Institute for Immunology, 478, Grenzacherstrasse CH 4058, Basel, Switzerland

Jonathan W. Uhr,     Department of Microbiology, University of Texas, Southwestern Medical School, Dallas, Texas 75235

Emil R. Unanue,     Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115

Harald von Boehmer,     Basel Institute for Immunology, 487 Grenzacherstrasse CH 4058, Basel, Switzerland

Jon J. van Rood,     Department of Immunohematology, University Hospital, Leiden, The Netherlands

Ellen Vitetta,     Department of Microbiology, University of Texas, Southwestern Medical School, Dallas, Texas 75235

Hans Wigzell,     Department of Immunology, Uppsala University, Uppsala, Sweden

Darcy B. Wilson,     Department of Pathology, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania 19174

Edmond J. Yunis,     University of Minnesota Hospital,...

Produkt-Details

• Erscheint lt. Verlag: 28.6.2014
• Sprache: englisch
• Themenwelt: Mathematik / Informatik ► Mathematik ► Geometrie / Topologie
• Themenwelt: Naturwissenschaften ► Biologie
• Themenwelt: Naturwissenschaften ► Physik / Astronomie ► Angewandte Physik
• Themenwelt: Technik
• ISBN-10: 1-4832-7344-X / 148327344X
• ISBN-13: 978-1-4832-7344-0 / 9781483273440