Biophysics of DNA-Antibiotic Complexes

Nikolai Vekshin (Autor)

Buch | Hardcover

171 Seiten

2011
Nova Science Publishers Inc (Verlag)
9781617611995 (ISBN)

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Presents the basic results on studies of the interaction of anti-cancer Actinomycin antibiotics with DNA. This book focuses on interactions of heterocyclic anti-tumour antibiotics (Actinomycins, as typical example) with DNA, poly-nucleotides, oligonucleotides, and aggregates of purines, using spectroscopic methods.

This book presents the basic results on studies of the interaction of anti-cancer Actinomycin antibiotics with DNA. It focuses on interactions of heterocyclic anti-tumour antibiotics (Actinomycins, as typical example) with DNA, poly-nucleotides, oligonucleotides, and aggregates of purines, using spectroscopic methods. Experimental data, various models of structures of the complexes and their physical and chemical properties are described, and possible approaches for delivery of heterocyclic antibiotics to DNA are also discussed.

Preface; Introduction; Formation of complexes with DNA; Spectral properties of Actinomycins; Cluster sites in DNA; Single-chain structures & Actinomycins; Spectroscopic analysis of DNA in films; Fluorescence correlation spectroscopy of 7AAMD; The problem of delivery of antibiotics to the cellular DNA; Action of Actinomycin and caffeine on Saccharomyces; Displacement of 7AAMD in HP1 by Hoechst; Conclusion; Index.

Zusatzinfo	Illustrations
Verlagsort	New York
Sprache	englisch
Maße	230 x 155 mm
Gewicht	426 g
Themenwelt	Informatik ► Weitere Themen ► Bioinformatik
	Naturwissenschaften ► Biologie ► Biochemie
	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
ISBN-13	9781617611995 / 9781617611995
Zustand	Neuware