Right to be Intelligent (eBook)

L.A. Machado (Autor)

eBook Download: PDF

2013 | 1. Auflage
70 Seiten
Elsevier Science (Verlag)
9781483285757 (ISBN)

Infos

'The only weapon effective against State force is the intellectual power of the citizens'. In this first translation of his bestseller in the Spanish-speaking world, Dr. Machado advances the fundamental tenets for humane socialism in the developing Third World. The colossal technological dominance by the developed nations must be faced by a strong and ringing claim to the educational emancipation which opposes totalitarianism and technocracy alike. 'No one is born civilised or primitive. The difference...is educational' - with this opening salvo Dr. Machado starts his demolition of the passive notions of 'natural intelligence' and 'natural superiority' which smooth the totalitarian path

Inhalt

Front Cover 1
Biotechnology of Blood 6
Copyright Page 7
Table of Contents 10
PART I: OXYGEN DELIVERY SYSTEMS 16
Chapter 1. Biotechnology, Economies, and the Business of Blood 18
1.1 Cellular Components and Biotechnology 20
1.2 Plasma Products 36
References 43
Chapter 2. Long-Term Storage and Preservation of Red Blood Cells 46
2.1 Current State of Liquid Preservation at 4°C 47
2.2 Current Research in Nonfrozen Systems 49
2.3 Frozen Red Cells 53
2.4 Post-Thaw Preservation of Red Cells 55
2.5 Conclusions 59
References 59
Chapter 3. Autologous Blood Salvage Procedures 62
3.1 Advantages of Autologous Transfusion 63
3.2 Clinical Applications 64
3.3 Contraindications 65
3.4 Intraoperative Blood Salvage Devices 66
3.5 Postoperative Blood Salvage 78
3.6 Complications 81
3.7 Characteristics of Salvaged Blood 82
3.8 Administrative Considerations 83
3.9 Summary 84
References 86
Chapter 4. The Production of Group O Cells 90
4.1 Biochemistry, Genetics, and Formation of the ABO Blood Group Antigens 91
4.2 Treatment Conditions Compatible with RBC Viability 94
4.3 Enzymatic Conversion of Group B RBC to Group O: In Vivo Studies 98
4.4 Enzymatic Conversion of Group A RBC to Group O: In Vitro Studies 109
4.5 Future Perspectives: Rh Modification 112
References 113
Chapter 5. Chemically Modified and Recombinant Hemoglobin Blood Substitutes 116
5.1 Regulation of the Oxygen Affinity of Hemoglobin 117
5.2 Dissociation of the Hemoglobin Tetramer 119
5.3 Chemical Modification of Hemoglobin 120
5.4 Purification of Hemoglobin 123
5.5 Autooxidation of Hemoglobin 123
5.6 Recombinant Production of Hemoglobin 127
5.7 Summary 129
References 130
Chapter 6. Liposome-Encapsulated Hemoglobin: Historical Development of a Blood Substitute 132
6.1 Fabrication 133
6.2 In Vivo Studies 135
6.3 Future Directions 137
References 139
Chapter 7. Medical Oxygen Transport Using Perfluorochemicals 142
7.1 History of Perfluorochemicals in Oxygen Transport 143
7.2 Data on the Use of PFC Emulsions 144
7.3 Medical Applications and Clinical Studies 147
7.4 Future Perfluorochemical Products 170
7.5 Conclusion 172
References 173
PART II: PLASMA FRACTIONS 178
Chapter 8. Current Approaches to the Preparation of Plasma Fractions 180
8.1 Albumin 181
8.2 Plasma Protein Fraction 183
8.3 Antihemophilic Factor (Factor VIII, or AHF) 183
8.4 Immunoglobulins 184
8.5 Fibrinogen 186
8.6 Prothrombin Complex 186
8.7 Activated Prothrombin Complex Concentrates 187
8.8 Antithrombin III 187
8.9 Current Equipment and Technologies Used in Plasma Fractionation 188
References 190
Chapter 9. Recombinant Antihemophilic Factors 192
9.1 Factor VIII 195
9.2 Factor IX 198
9.3 Factor VII 202
9.4 Other Recombinant Coagulation Factors 204
9.5 Conclusion 207
References 208
Chapter 10. Recombinant Tissue-Type Plasminogen Activator 212
10.1 The Fibrinolytic System 212
10.2 Nonrecombinant Tissue-Type Plasminogen Activator (t-PA) 214
10.3 Recombinant Tissue-Type Plasminogen Activator (rt-PA) 219
10.4 Mutants and Variants of Tissue-Type Plasminogen Activator 227
10.5 Conclusions 233
References 233
Chapter 11. Fibrinogen and Fibrin Formation and Its Role in Fibrinolysis 240
11.1 Introduction 240
11.2 Physicochemical Properties of Fibrinogen 241
11.3 Chains and Prosthetic Groups of Fibrinogen 245
11.4 Primary Structure of Fibrinogen 247
11.5 Activation of Fibrinogen 251
11.6 Fibrin(ogen)olysis in Presence of Plasmin 267
11.7 Interaction of Fibrinogen and Fibrin with Ions, Plasma Proteins, and Cells 270
11.8 Biosynthesis of Fibrinogen 272
11.9 Evolution of Fibrinogen and Hemostatic Mechanisms 274
11.10 Role of Fibrinogen in Health and Disease 277
References 284
Chapter 12. Fibrinogen-Fibrin: Preparation and Use of Monoclonal Antibodies as Diagnostics 296
12.1 Fibrinogen-to-Fibrin Transition and Fibrin(ogen)olysis 297
12.2 Monitoring Blood Levels of Fibrin(ogen) Degradation Products 298
12.3 Characterization of Fibrin(ogen) Antigens in Tissues 307
12.4 Monoclonal Antibodies as Thrombus Imaging Agents 316
Abbreviations and Terms 324
References 325
PART III: IN VIVO AND IN VITRO REGULATION OF BLOOD CELL PRODUCTION 330
Chapter 13. Hematopoietic Stem Cell Processing and Storage 332
13.1 Hematopoietic Stem Cell Collection and Processing 333
13.2 Hematopoietic Stem Cell Storage 354
13.3 Summary and Conclusions 359
References 360
Chapter 14. Erythropoietin: Its Role in the Regulation of Erythropoiesis and as a Therapeutic in Humans 366
14.1 The Erythropoietin (Epo) Gene 366
14.2 Regulation of Epo Production 368
14.3 Plasma Epo 369
14.4 Interactions of Epo with Its Target Cell 370
14.5 Epo as a Therapeutic Treatment 372
14.6 Summary 377
References 377
Chpater 15. Hematopoietic Colony-Stimulating Factors 380
15.1 Biotechnology of CSFs 383
15.2 Multi-CSF 384
15.3 GM-CSF 389
15.4 G-CSF 395
15.5 M-CSF 397
15.6 Summary 403
References 426
Chapter 16. Long-Term Bone Marrow Cell Cultures 412
16.1 Evolving Hierarchy of Hematopoietic Progenitors 414
16.2 Hematopoietic Microenvironment 418
16.3 Clinical Applications—Current and Future 423
References 426
PART IV: Blood-Borne Viral Diseases 430
Chapter 17. Inactivation of Viruses Found with Plasma Proteins 432
17.1 Viral Risk from Single Units of Blood 432
17.2 Viral Risk from Plasma Protein Fractions 433
17.3 Summary and Conclusion 441
References 443
Chapter 18. Inactivation of Viruses Found with Cellular Components 446
18.1 Physical Methods for Virus Removal or Inactivation 448
18.2 Immune Neutralization 450
18.3 Hydrolyzable Chemical Agents 450
18.4 Photosensitization Techniques 452
18.5 Irradiation Methods 457
18.6 Summary and Conclusions 459
References 462
Index 466

Produkt-Details

• Erscheint lt. Verlag: 22.10.2013
• Sprache: englisch
• Themenwelt: Geisteswissenschaften ► Psychologie ► Allgemeine Psychologie
• Themenwelt: Geisteswissenschaften ► Psychologie ► Verhaltenstherapie
• Themenwelt: Technik
• ISBN-13: 9781483285757 / 9781483285757