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Pharmacogenomics in Admixed Populations

. G. Suarez-Kurtz (Autor)

Buch | Hardcover

222 Seiten

2007
CRC Press (Verlag)
978-1-58706-311-4 (ISBN)

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Ethnic specificity has become an integral part of research in the overlapping sciences of pharmacogenetics and pharmacogenomics. Pharmacogenomics in Admixed Populations was conceived to compile pharmacogenetic/-genomic (PGx) data from peoples of four continents: Africa, America, Asia and Oceania, where admixture and population stratification occurs in distinct patterns. The organization of this book was formed by a population PGx perspective: an initial review of the evolution of human genetic diversity leads into a series of chapters dealing with the population structure, and the PGx profiles, of various peoples selected on the basis of continents, countries or particular sub-groups within a continent or country.

Dr. G. Suarez-Kurtz, is Head of Pharmacology at the Brazilian National Cancer Institute— INCA— Coordinator of the Brazilian National Pharmacogenomics Network— REFARGEN— and a member of the Committee on Pharmacogenetics of the International Union of Pharmacology— IUPHAR. A pioneer of pharmacogenetic studies in the Brazilian population, his research explores the impact o f genetic admixture on the conceptual development and the praxis of pharmacogenetics/-genomics. He is a Full Member of the Brazilian Academy of Sciences, a Senior Investigator of the Brazilian National Research Council— CNPq— and a Professor of Clinical and Basic Pharmacology at Universidade do Brasil in Rio de Janeiro, where he received his M.D. and Ph.D. degrees. He did postgraduate work at Faculté de Médecine de Paris, Columbia University, New York and University College, London.

Preface 1. The Evolution and Structure of Human Genetic Diversity 2. Controlling the Effects of Population Stratification by Admixture in Pharmacogenetics 3. Admixture in North America 4. Pharmacogenetics in the African American Population 5. Pharmacogenetics of Cytochrome P450 in Hispanic Populations 7. Pharmacogenetics of Cytochrome P450s in African Populations: Clinical and Molecular Evolutionary Implications 8. Pharmacogenomics in the Indian Population 9. Pharmacogenetics and Ethnicity: An Asian Perspective 10. Pharmacogenetics in Chinese Population 11. Pharmacogenetics in Admixed Polynesian Populations 12. Pharmacogenetics, Ethnic Differences in Drug Response and Drug Regulation 13. Human Genomic Variation Studies and Pharmacogenomics Are Critical for Global Health 14. Synopsis and Perspectives

Zusatzinfo	33 Illustrations, black and white
Verlagsort	London
Sprache	englisch
Maße	152 x 229 mm
Gewicht	453 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
Themenwelt	Naturwissenschaften ► Biologie
ISBN-10	1-58706-311-5 / 1587063115
ISBN-13	978-1-58706-311-4 / 9781587063114
Zustand	Neuware