Concepts and Models for Drug Permeability Studies (eBook)

Cell and Tissue based In Vitro Culture Models

Jose das Neves, Catarina Leite Pereira, Bruno Sarmento (Autoren)

eBook Download: PDF | EPUB

2024 | 2. Auflage
500 Seiten
Elsevier Science (Verlag)
978-0-443-15511-6 (ISBN)

Infos

Dr. Leite Pereira is a Junior Researcher at Institute for Research and Innovation in Health (i3S), University of Porto (UP). Her research focus on the development of advanced 3D in vitro models as preclinical tools for novel drugs/nanomedicines screening, using multi-compartmentalized in vitro systems. Throughout her path Catarina has been able to translate her scientific achievements into the publication of 27 papers in leading peer-reviewed journals (h-index: 15, >500 citations). The quality of the scientific production can be ascertained by the several selected oral presentations in prestigious international conferences and invitations to act as expert reviewer in international funding agencies.

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Concepts and Models for Drug Permeability Studies: Cell and Tissue Based in Vitro Culture Models, Second Edition, summarizes the most important developments in in vitro models for predicting the permeability of drugs. This book is structured around three different approaches, summarizing the most recent achievements regarding models comprising (i) immortalized cells with an intrinsic ability to grow as monolayers when seeded in permeable supports, (ii) primary cells isolated from living organisms and directly cultured as barrier monolayers, and (iii) tissue-based models constructed with cell lines and extracellular matrix that resembles the tridimensional structure of mucosae and other biological membranes, or animal/patient-derived tissues. Each model is covered in detail, including the protocol of generation and application for specific drugs/drug delivery systems. The equivalence between in vitro cell and tissue models and in vivo conditions is discussed, highlighting how each model may provisionally resemble different drug absorption route. Chapters included in the first edition were updated with relevant data published in recent years, while four new chapters were included to reflect new emerging directions and trends in drug permeability models. Concepts and Models for Drug Permeability Studies: Cell and Tissue Based in Vitro Culture Models, Second Edition, is a critical reference for drug discovery and drug formulation scientists interested in delivery systems intended for the administration of drugs through mucosal routes and other important tissue barriers (e.g. the BBB). Researchers studying mucosal biology can use this book to familiarize themselves and exploit the synergic effect of mucosal delivery systems and biomolecules.Summarizes the current advances in the use of permeability models in drug transportCovers the most important buccal, gastric, intestinal, pulmonary, nasal, vaginal, ocular, renal, skin, and blood-brain barrier in vitro models. Includes case studies to facilitate understanding of various concepts in computer-aided applicationsUpdates in the second edition include organ-on-chip devices, 3D advanced models (multiple layered tissues, organoids, etc.), and multicompartmentalized tissue models

Produkt-Details

• Erscheint lt. Verlag: 23.2.2024
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
• Themenwelt: Medizin / Pharmazie ► Pharmazie
• Themenwelt: Technik
• Themenwelt: Wirtschaft
• ISBN-10: 0-443-15511-9 / 0443155119
• ISBN-13: 978-0-443-15511-6 / 9780443155116