Comparative Gene Finding

Models, Algorithms and Implementation

Marina Axelson-Fisk (Autor)

Buch | Hardcover

382 Seiten

2015 | 2nd ed. 2015
Springer London Ltd (Verlag)
978-1-4471-6692-4 (ISBN)

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This book presents a guide to building computational gene finders, and describes the state of the art in computational gene finding methods, with a focus on comparative approaches. Fully updated and expanded, this new edition examines next-generation sequencing (NGS) technology. The book also discusses conditional random fields, enhancing the broad coverage of topics spanning probability theory, statistics, information theory, optimization theory and numerical analysis. Features: introduces the fundamental terms and concepts in the field; discusses algorithms for single-species gene finding, and approaches to pairwise and multiple sequence alignments, then describes how the strengths in both areas can be combined to improve the accuracy of gene finding; explores the gene features most commonly captured by a computational gene model, and explains the basics of parameter training; illustrates how to implement a comparative gene finder; examines NGS techniques and how to build a genome annotation pipeline.

Introduction.- Single Species Gene Finding.- Sequence Alignment.- Comparative Gene Finding.- Gene Structure Submodels.- Parameter Training.- Implementation of a Comparative Gene Finder.- Annotation Pipelines for Next Generation Sequencing Projects.

Reihe/Serie	Computational Biology ; 20
Zusatzinfo	81 Illustrations, black and white; XX, 382 p. 81 illus.
Verlagsort	London
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Informatik ► Weitere Themen ► Bioinformatik
	Naturwissenschaften ► Biologie ► Biochemie
	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
Schlagworte	algorithms • Bioinformatics • Biological sequence analysis • comparative genomics • Computational Biology • Computational Gene Finding • genes • Genetics • Information Theory • sequence alignment
ISBN-10	1-4471-6692-2 / 1447166922
ISBN-13	978-1-4471-6692-4 / 9781447166924
Zustand	Neuware