Breathborne Biomarkers and the Human Volatilome

Jonathan Beauchamp, Cristina Davis, Joachim Pleil (Herausgeber)

Buch | Softcover

722 Seiten

2020 | 2nd edition
Elsevier Science Publishing Co Inc (Verlag)
978-0-12-819967-1 (ISBN)

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Breathborne biomarkers carry information on the state of human health, and their role in aiding clinical diagnosis or in therapeutic monitoring has become increasingly important as advances in the field are made. Breathborne Biomarkers and the Human Volatilome, Second Edition, provides a comprehensive update and reworking of the 2013 book Volatile Biomarkers, by Anton Amann and David Smith. The new editing team has expanded this edition beyond volatile organic compounds to cover the broad field of breath analysis, including the many exciting developments that have occurred since the first edition was published. This thoroughly revised volume includes the latest discoveries and applications in breath research from the world's foremost scientists, and offers insights into related future developments. It is an ideal resource for researchers, scientists, and clinicians with an interest in breath analysis.

Jonathan Beauchamp is manager of the Emissions Analytics and Diagnostics group at the Fraunhofer Institute for Process Engineering and Packaging IVV in Freising, Germany. He has been involved in academic and industrial breath research for the past 15 years and is currently principal investigator in several breath-related projects. He is an active member and current treasurer of the International Association of Breath Research (IABR). Cristina Davis is chair and professor of Mechanical and Aerospace Engineering at the University of California Davis, United States. Her research focuses on development of novel chemical and biological sensor systems and biomarker identification in agriculture and human/animal health monitoring. She has 12 issued patents and has coauthored over 100 peer-reviewed journal articles and book chapters. She is current chair-elect of IABR. Joachim Pleil is adjunct professor at the University of North Carolina, School of Public Health, United States. He has published over 150 journal articles, many involving breath biomarker research and statistical interpretation of breath-based data. He has retired from US Environmental Protection Agency after 32 years as a research scientist. He is currently a consultant for NASA on a pilot breathing assessment project and is a founding member of IABR.

Foreword
Dedication
Preface

PART A: Concepts and modeling
1. Breath biomakers and the exposome
2. Breath sampling and standardization
3. Physiological modeling of exhaled compounds
4. Exhaled nitric oxide physiology and modeling

PART B: Inorganics and non-volatiles
5. Exhaled nitric oxide in clinical practice
6. Exhaled carbon monoxide
7. Exhaled breath condensate and aerosol
8. Exhaled particles

PART C: Analytics
9. Selected ion flow tube mass spectrometry
10. Proton transfer reaction—mass spectrometry
11. Ion mobility spectrometry
12. Secondary electrospray ionization
13. Sensor systems
14. Optical spectroscopy
15. Comprehensive gas chromatography-mass spectrometry
16. High-resolution mass spectrometry

PART D: Breath tests
17. 13C breath tests
18. Breath monitoring in the intensive care unit
19. Chronic obstructive pulmonary disease and smokers
20. Clinical phenotyping
21. Breath analysis for respiratory infections
22. Volatile biomarkers of malaria infection
23. Lifestyle applications

PART E: Beyond human breath
24. Biomarkers in urine and stool
25. Volatile emissions from skin
26. Cell cultures as in vitro models for breath research
27. Ruminants
28. Breath analysis in marine mammals

PART F: Field applications
29. Breath analysis in law enforcement
30. Drugs in breath
31. Urban search and rescue
32. Breath analysis in occupational medicine
33. Breath biomarkers in human xenobiotic exposure studies
34. Canine olfaction

PART G: Design and interpretation
35. Clinical study design
36. Challenges in clinical breath research development
37. Mathematical interpretation of targeted volatilome data
38. Preprocessing and analysis of volatilome data
39. Applications of the US EPA CompTox Chemicals Dashboard to support mass spectrometry and breath research

Erscheinungsdatum	15.06.2020
Sprache	englisch
Maße	191 x 235 mm
Gewicht	1480 g
Themenwelt	Studium ► 2. Studienabschnitt (Klinik) ► Anamnese / Körperliche Untersuchung
Themenwelt	Naturwissenschaften ► Chemie ► Analytische Chemie
ISBN-10	0-12-819967-9 / 0128199679
ISBN-13	978-0-12-819967-1 / 9780128199671
Zustand	Neuware