Chordoma of the Spine

A Comprehensive Review

Daniel M. Sciubba, Joseph H. Schwab (Herausgeber)

Buch | Softcover

XX, 307 Seiten

2022 | 1st ed. 2021
Springer International Publishing (Verlag)
978-3-030-76203-2 (ISBN)

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This book provides a comprehensive review of the epidemiology, pathogenesis, diagnosis, and management of chordomas of the mobile spine and sacrum. Historically, knowledge about how to deliver such state-of-the-art care has not been widespread, resulting in inconsistent treatment, and, all too often, suboptimal outcomes for chordoma patients. This text is an important step towards broadening that knowledge, and, in turn, improving the care provided to chordoma patients. The book is divided into 4 parts comprising 16 chapters. The first part focuses on the pathophysiology and molecular drivers of chordoma. The second focuses on the epidemiology and clinical history, as well as the histological, oncologic, and radiographic work-up of chordoma. The third part focuses primarily on the technical aspects of surgery for chordoma. It is broken down by anatomic region, with the final two chapters focusing on the soft tissue and bony reconstruction following chordoma resection. The last part focuses on the exciting field of adjuvant therapies for chordoma. This includes both radiation therapies and novel chemotherapeutic options for recurrent, metastatic, and dedifferentiated chordoma.
Written by world experts from leading chordoma centers, Chordoma of the Spine serves as a valuable reference for spinal oncologists and general spine surgeons who may encounter chordoma patients in their practice. It provides the most up-to-date evidence regarding all aspects of treating patients with this disease. By focusing on this specific pathology of the spine, this resource condenses expert-level research into understandable treatment algorithms.

lt;p>Daniel M. Sciubba
Department of Neurosurgery
Zucker School of Medicine at Hofstra University/Northwell Health
Manhasset, NY
USA

Section IPathophysiology and Molecular Mechanisms of Chordoma
1Notochordal Morphogenesis and the Origin of ChordomaMatthew L. Goodwin, MD PhD, David C. Clever, MD PhD2Molecular and Genetic Mechanisms of Spinal ChordomaConnor Liu, BS; Ann Liu, MD; Chetan Bettegowda, MD/PhD
Section IIEpidemiology, Clinical History, and Work-Up for Chordoma
3Historical Overview, Demographics, and Clinical Presentation of Spinal ChordomaZach Pennington BS, Andrew Schilling AB, Joseph H. Schwab MS MS, Daniel M. Sciubba MD4Clinical Work up, Diagnostic Imaging and BiopsyDaniel Ryan, MD; John Gross, MD; Zach Pennington BS, Majid Khan, MD5Histopathologic Classification of Spinal ChordomaJohn M Gross MD, Edward F McCarthy MD6Multi-disciplinary Planning for TreatmentNicholas A Shepard MD, Matthew W Colman MD
Section IIISurgical Management of Chordoma
7Surgical Management of Chordoma of the Occipitocervical JunctionZach Pennington BS, Jeff Ehresman BS, Andrew Schilling BA, Daniel M. Sciubba MD8Surgical Management of Chordoma of the Cervical SpineOliver G.S. Ayling MD, MSc, Nicolas Dea MD, MSc9Surgical Management of Chordoma of the Thoracic SpineDaniel G. Tobert MD, John H. Shin MD, Joseph H. Schwab MD10Surgical Management of Chordoma of the Lumbar SpineSutipat Pairojboriboon MD, Amanda Sacino MDPhD, Sheng-fu Larry Lo MD11Surgical Management of Chordoma of the SacrumPeter S. Rose, MD, Matthew T. Houdek, MD, Cory G. Couch, MD12Soft Tissue Reconstruction Following Surgery for Sacral ChordomaRachel Skladman MD, Zach Pennington BS, Justin M. Sacks MD MBA FACS13Vascular Reconstruction After EnBloc Resection.Daniel G. Tobert MD, Joseph H. Schwab MD
Section IVRadiation and Chemotherapeutic Adjuvants for Chordoma
14Photon Therapy for Chordoma of the SpineChunzi Jenny Jin MD MSc, Yoshiya Josh Yamada MD FRCPC15Heavy Particle Therapy for ChordomaDavid J. Konieczkowski MD PhD, Reiko Imai MD, Thomas F. DeLaney MD16Systemic Therapy, Trials and Future Directions for Chordoma of the SpineDaniel J. Zabransky, MD, PhD, Zach Pennington BS, Christian Meyer, MD, MS, PhD
Index

Erscheinungsdatum	26.07.2022
Zusatzinfo	XX, 307 p. 96 illus., 62 illus. in color.
Verlagsort	Cham
Sprache	englisch
Maße	155 x 235 mm
Gewicht	498 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Chirurgie
Schlagworte	Heavy Particle Therapy • Histopathologic Classification • Notochordal Morphogenesis • radiation treatments • Systemic Therapy
ISBN-10	3-030-76203-3 / 3030762033
ISBN-13	978-3-030-76203-2 / 9783030762032
Zustand	Neuware