Textbook of Personalized Medicine
Springer International Publishing (Verlag)
978-3-030-62079-0 (ISBN)
This book is for personalized medicine as a prescription of specific treatments and therapeutics best suited for an individual and considers genetic as well as environmental factors that influence responses to therapy. Best approaches are described for integration of all available technologies for optimizing the therapy of individual patients.
This comprehensive third edition covers the latest advances in personalized medicine and several chapters are devoted to various specialties, particulary cancer which is the largest area of application. The book discusses the development of personalized medicine and various players in it such as companies, academic institutions, the government, and the public as the consumer of healthcare. Additionally, the roles of bioinformatics, electronic health records, and digital technologies for personalized medicine are discussed.
Textbook of Personalized Medicine, 3rd Edition serves as a convenient source of information for students at many levels and in a wide range of fields, including physicians, scientists, and decision makers in the biopharmaceutical and healthcare industries.
lt;p>Prof. K. K. Jain MD, FRACS, FFPM
Jain PharmaBiotech
Blaesiring 7
CH-4057 Basel, Switzerland
Preface to the 3rd edition
1 Basic Aspects
Definition of personalized medicine
History of medical concepts relevant to personalized medicine
Molecular biological basis of personalized medicine
Basics technologies for developing personalized medicine
'Omics' and personalized medicine
Conventional medicine versus personalized medicine
Personalized medicine and evidence-based medicine
Role of genetics in future approaches to healthcare
Role of systems biology in personalized medicine
Synthetic biology and development of personalized medicinesPersonalized digital medicine
A personalized approach to environmental factors in disease
Reclassification of diseases
Translational science and personalized medicine
Personalization of multimodal therapies
2 Molecular Diagnostics in Personalized Medicine
Introduction
Molecular diagnostic technologies
Sequencing
Biochips and microarrays
SNP genotyping
Detection of copy number variations
Study of rare variants in pinpointing disease-causing genes
Optical Mapping
Proteomics in molecular diagnosis
Role of nanobiotechnology in molecular diagnostics
Role of biosensors in personalized medicine
Gene expression profiling
Molecular imaging and personalized medicine
Combination of diagnostics and therapeutics
Point-of-care diagnosis
Genetic testing for disease predisposition
Combination of diagnostics with therapeutics
Future of molecular diagnostics in personalized medicine
3 Role of Biomarkers in Personalized Medicine
4 Pharmacogenetics
Basics of pharmacogenetics
Role of molecular diagnostics in pharmacogenetics
Role of pharmacogenetics in pharmaceutical industry
Clinical implications of pharmacogenetics
Limitations of pharmacogenetics
Pharmacoepigenomics vs pharmacogenetics in drug safety
Future role of pharmacogenetics in personalized medicine
5 Pharmacogenomics
Introduction
Basics of pharmacogenomics
Pharmacogenomics and drug discovery
Pharmacogenomics and clinical trials
Pharmacogenomic aspects of major therapeutic areas
Current status and future prospects of pharmacogenomics
6 Role of Pharmacoproteomics
Basics of proteomics
Proteomic approaches to the study of pathophysiology of diseases
Proteomic technologies for drug discovery and development
Applications of pharmacoproteomics in personalized medicine
7 Role of Metabolomics in Personalized Medicine
Metabolomics and metabonomics
Metabolomics bridges the gap between genotype and phenotype
Metabolomics, biomarkers and personalized medicine
Metabolomic technologies
Pharmacometabonomics
Metabonomic technologies for toxicology studies
Metabonomics/metabolomics and personalized nutrition
Metabolomics for personalized medicine
8 Role of Nanobiotechnology in Development of Personalized Medicine
9 Personalized Biological Therapies
Introduction
Recombinant human proteins
Therapeutic monoclonal antibodies
Cell therapy
Gene therapy
Personalized vaccines
Antisense therapy
10 Personalized Non-pharmacological Therapies
Introduction
Acupuncture
Personalized hyperbaric oxygen therapy
Personalized nutrition
Personalized physical exercise
Personalized surgery
11 Personalized Therapy of Cancer
12 Personalized Therapy of Neurological Disorders
13 Personalized Therapy of Psychiatric Disorders
14 Personalized Therapy of Cardiovascular Disorders
15 Personalized Therapy of Pulmonary Disorders
16 Personalized Therapy Infectious Diseases
17 Personalized Approaches in Immunology
18 Personalized Management of Genetic Disorders
19 Personalized Management of Miscellaneous Disorders
Personalized management of DNA repair disorders
Personalized preventive medicine
Personalized management of ophthalmic disorders
Personalized management of skin disorders
Personalized urology
Personalized therapy of rheumatoid arthritis
Personalized management of obesity
Personalized management of diabetesManagement of genetic disorders
Personalized management of gastrointestinal disorders
Personalized approaches to improve organ transplantation
Personalized approaches to addiction
Personalized geriatrics
Personalized pediatrics
Personalized nephrology
Personalized gynecology
20 Development of Personalized Medicine
Introduction
Non-genomic factors in the development of personalized medicine
Players in the development of personalized medicine
Role of genetic banking systems and databases
Role of bioinformatics in development of personalized medicine
Integration of technologies for personalized medicine
Global scope of personalized medicine
Advantages of personalized medicine
Limitations of personalized medicine
Future of personalized medicine
21 Ethical Aspects of Personalized Medicine
22 Legal Aspects of Personalized Medicine
23 Regulatory Aspects of Personalized Medicine
FDA and personalized medicine
FDA and molecular diagnostics in relation to personalized medicine
Regulatory aspects of pharmacogenetics
Regulation of direct-to-consumer genetic testing
FDA and pharmacogenomics
FDA and predictive medicine
24 Economics of Personalized Medicine
25 Future of Personalized Medicine
| Erscheinungsdatum | 05.01.2021 |
|---|---|
| Zusatzinfo | XLIII, 744 p. 41 illus., 5 illus. in color. |
| Verlagsort | Cham |
| Sprache | englisch |
| Maße | 178 x 254 mm |
| Gewicht | 1940 g |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie |
| Schlagworte | Biotechnology • clinical use • Disorder management • Genomic Medicine • Individualized Therapy • Molecular Diagnostics • Personalized medicine • Personalized treatment • Pharmacogenetics • Pharmacogenomics • Pharmacological therapy • pharmacotherapy • Precision medicine |
| ISBN-10 | 3-030-62079-4 / 3030620794 |
| ISBN-13 | 978-3-030-62079-0 / 9783030620790 |
| Zustand | Neuware |
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